Odorant-binding protein 2A

Odorant-binding protein 2a is a protein that in humans is encoded by the OBP2A gene.[5]

OBP2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RUN
Identifiers
Aliases	OBP2A, LCN13, OBP, OBP2C, OBPIIa, hOBPIIa, odorant binding protein 2A
External IDs	OMIM: 164320 MGI: 3651927 HomoloGene: 135821 GeneCards: OBP2A
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 135,546,139 bp[1] End 135,549,969 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,737,009 bp[2] End 25,740,097 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • odorant binding • small molecule binding Cellular component • extracellular region • cellular component Biological process • sensory perception of chemical stimulus • sensory perception of smell • response to stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29991	383678
Ensembl	ENSG00000122136	ENSMUSG00000079539
UniProt	Q9NY56	A2BHR0
RefSeq (mRNA)	NM_001293189 NM_001293193 NM_014582	NM_001099301 NM_001378280
RefSeq (protein)	NP_001280118 NP_001280122 NP_055397	NP_001092771 NP_001365209
Location (UCSC)	Chr 9: 135.55 – 135.55 Mb	Chr 2: 25.74 – 25.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000122136 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OBP2A odorant binding protein 2A".

Further reading

• Tegoni M, Pelosi P, Vincent F, et al. (2000). "Mammalian odorant binding proteins". Biochim. Biophys. Acta. 1482 (1–2): 229–40. doi:10.1016/S0167-4838(00)00167-9. PMID 11058764.
• Tcatchoff L, Nespoulous C, Pernollet JC, Briand L (2006). "A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes". FEBS Lett. 580 (8): 2102–8. doi:10.1016/j.febslet.2006.03.017. PMID 16546182.
• Breustedt DA, Schönfeld DL, Skerra A (2006). "Comparative ligand-binding analysis of ten human lipocalins". Biochim. Biophys. Acta. 1764 (2): 161–73. doi:10.1016/j.bbapap.2005.12.006. PMID 16461020.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matarazzo V, Zsürger N, Guillemot JC, et al. (2003). "Porcine odorant-binding protein selectively binds to a human olfactory receptor". Chem. Senses. 27 (8): 691–701. doi:10.1093/chemse/27.8.691. PMID 12379593.
• Briand L, Eloit C, Nespoulous C, et al. (2002). "Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties". Biochemistry. 41 (23): 7241–52. doi:10.1021/bi015916c. PMID 12044155.
• Lacazette E, Gachon AM, Pitiot G (2000). "A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres". Hum. Mol. Genet. 9 (2): 289–301. doi:10.1093/hmg/9.2.289. PMID 10607840.