Nucleoporin 188

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.[5][6]

NUP188
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IJO
Identifiers
Aliases	NUP188, KIAA0169, hNup188, nucleoporin 188kDa, nucleoporin 188, SANDSTEF
External IDs	OMIM: 615587 MGI: 2446190 HomoloGene: 45683 GeneCards: NUP188
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,947,699 bp[1] End 129,007,096 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,286,397 bp[2] End 30,344,266 bp[2]
Gene ontology Molecular function • GO:0005487 structural constituent of nuclear pore Cellular component • nuclear pore • cell nucleus • nuclear pore inner ring • nuclear envelope • membrane • host cell Biological process • mitotic nuclear envelope disassembly • viral transcription • protein import into nucleus • GO:0022415 viral process • RNA export from nucleus • protein sumoylation • protein transport • mRNA transport • regulation of cellular response to heat • GO:0046795 intracellular transport of virus • glomerular visceral epithelial cell migration • mRNA export from nucleus • tRNA export from nucleus • regulation of gene silencing by miRNA • regulation of glycolytic process • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23511	227699
Ensembl	ENSG00000095319	ENSMUSG00000052533
UniProt	Q5SRE5	Q6ZQH8
RefSeq (mRNA)	NM_015354	NM_198304
RefSeq (protein)	NP_056169	NP_938046
Location (UCSC)	Chr 9: 128.95 – 129.01 Mb	Chr 2: 30.29 – 30.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP188 is part of one such subcomplex.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000095319 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052533 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NUP188 nucleoporin 188kDa".
6. Miller BR, Powers M, Park M, Fischer W, Forbes DJ (October 2000). "Identification of a New Vertebrate Nucleoporin, Nup188, with the Use of a Novel Organelle Trap Assay". Mol. Biol. Cell. 11 (10): 3381–96. doi:10.1091/mbc.11.10.3381. PMC 15000. PMID 11029043.

External links

• Overview of all the structural information available in the PDB for UniProt: Q5SRE5 (Human Nucleoporin NUP188 homolog (NUP188)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.