Nucleoporin 188

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.[5][6]

NUP188
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP188, KIAA0169, hNup188, nucleoporin 188kDa, nucleoporin 188, SANDSTEF
External IDsOMIM: 615587 MGI: 2446190 HomoloGene: 45683 GeneCards: NUP188
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.11Start128,947,699 bp[1]
End129,007,096 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23511

227699

Ensembl

ENSG00000095319

ENSMUSG00000052533

UniProt

Q5SRE5

Q6ZQH8

RefSeq (mRNA)

NM_015354

NM_198304

RefSeq (protein)

NP_056169

NP_938046

Location (UCSC)Chr 9: 128.95 – 129.01 MbChr 2: 30.29 – 30.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP188 is part of one such subcomplex.[5]

gollark: BetterThanGo™
gollark: - Most functions return `Result`s.- Outofbounds access, for example, can `panic` for not really handleable situations.- You can use the `?` operator which sticks in an early return (returning the errory thing, obviously) if it's an error or otherwise just returns the value of the `Ok`.- You can also do valid-result-or-panic with the `unwrap`/`expect` method.- Panics are isolated to threads.
gollark: Rust handles totality quite well, I think.
gollark: A runtime error?!
gollark: Oh, really?

References
  1. GRCh38: Ensembl release 89: ENSG00000095319 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052533 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NUP188 nucleoporin 188kDa".
  6. Miller BR, Powers M, Park M, Fischer W, Forbes DJ (October 2000). "Identification of a New Vertebrate Nucleoporin, Nup188, with the Use of a Novel Organelle Trap Assay". Mol. Biol. Cell. 11 (10): 3381–96. doi:10.1091/mbc.11.10.3381. PMC 15000. PMID 11029043.
  • Overview of all the structural information available in the PDB for UniProt: Q5SRE5 (Human Nucleoporin NUP188 homolog (NUP188)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.