NFASC

Neurofascin is a protein that in humans is encoded by the NFASC gene.[5][6][7]

NFASC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P3Y, 3P40
Identifiers
Aliases	NFASC, NF, NRCAML, neurofascin, NEDCPMD
External IDs	OMIM: 609145 MGI: 104753 HomoloGene: 24945 GeneCards: NFASC
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,828,651 bp[1] End 205,022,822 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 57.42 cM Start 132,564,690 bp[2] End 132,741,797 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • GO:0001948 protein binding • protein binding involved in heterotypic cell-cell adhesion Cellular component • integral component of membrane • membrane • focal adhesion • myelin • cell membrane • Schwann cell microvillus • intracellular • axon • paranodal junction • axon initial segment • paranode region of axon • extracellular exosome • node of Ranvier • ficolin-1-rich granule membrane • dendrite • integral component of plasma membrane Biological process • clustering of voltage-gated sodium channels • peripheral nervous system development • transmission of nerve impulse • heterotypic cell-cell adhesion • synapse organization • protein localization to paranode region of axon • cell adhesion • paranodal junction assembly • myelination • protein localization to juxtaparanode region of axon • axon guidance • neutrophil degranulation • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23114	269116
Ensembl	ENSG00000163531	ENSMUSG00000026442
UniProt	O94856	Q810U3
RefSeq (mRNA)	NM_001005387 NM_001005388 NM_001005389 NM_001160331 NM_001160332 NM_001160333 NM_015090 NM_001365986 NM_001378330 NM_001378331 NM_001378329	NM_001160316 NM_001160317 NM_001160318 NM_182716
RefSeq (protein)	NP_001005388 NP_001005389 NP_001153803 NP_001153804 NP_001153805 NP_055905 NP_001352915 NP_001365259 NP_001365260 NP_001365258	NP_001153788 NP_001153789 NP_001153790 NP_874385
Location (UCSC)	Chr 1: 204.83 – 205.02 Mb	Chr 1: 132.56 – 132.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Neurofascin is an L1 family immunoglobulin cell adhesion molecule (see L1CAM) involved in axon subcellular targeting and synapse formation during neural development.[7][8]

Clinical importance

A homozygous mutation causing loss of Nfasc155 causes severe congenital hypotonia, contractures of fingers and toes and no reaction to touch or pain.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000163531 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026442 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Volkmer H, Hassel B, Wolff JM, Frank R, Rathjen FG (July 1992). "Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily". The Journal of Cell Biology. 118 (1): 149–61. doi:10.1083/jcb.118.1.149. PMC 2289533. PMID 1377696.
6. Burmeister M, Ren Q, Makris GJ, Samson D, Bennett V (July 1996). "Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes". Mammalian Genome. 7 (7): 558–9. doi:10.1007/s003359900168. PMID 8672144.
7. "Entrez Gene: NFASC neurofascin homolog (chicken)".
8. Ango F, di Cristo G, Higashiyama H, Bennett V, Wu P, Huang ZJ (October 2004). "Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment". Cell. 119 (2): 257–72. doi:10.1016/j.cell.2004.10.004. PMID 15479642.
9. Smigiel R, Sherman DL, Rydzanicz M, Walczak A, Mikolajkow D, Krolak-Olejnik B, Kosinska J, Gasperowicz P, Biernacka A, Stawinski P, Marciniak M, Andrzejewski W, Boczar M, Krajewski P, Sasiadek MM, Brophy PJ, Ploski R (August 2018). "Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia". Human Molecular Genetics. 27 (21): 3669–3674. doi:10.1093/hmg/ddy277. PMC 6196652. PMID 30124836.

Further reading

• Hortsch M (October 1996). "The L1 family of neural cell adhesion molecules: old proteins performing new tricks". Neuron. 17 (4): 587–93. doi:10.1016/S0896-6273(00)80192-0. PMID 8893017.
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Tuvia S, Garver TD, Bennett V (November 1997). "The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation". Proceedings of the National Academy of Sciences of the United States of America. 94 (24): 12957–62. Bibcode:1997PNAS...9412957T. doi:10.1073/pnas.94.24.12957. PMC 24245. PMID 9371782.
• Ren Q, Bennett V (May 1998). "Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules". Journal of Neurochemistry. 70 (5): 1839–49. doi:10.1046/j.1471-4159.1998.70051839.x. PMID 9572267.
• Zhang X, Davis JQ, Carpenter S, Bennett V (November 1998). "Structural requirements for association of neurofascin with ankyrin". The Journal of Biological Chemistry. 273 (46): 30785–94. doi:10.1074/jbc.273.46.30785. PMID 9804856.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Koroll M, Rathjen FG, Volkmer H (April 2001). "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity". The Journal of Biological Chemistry. 276 (14): 10646–54. doi:10.1074/jbc.M010647200. PMID 11152476.
• Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA (July 2001). "Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain". The Journal of Cell Biology. 154 (2): 427–34. doi:10.1083/jcb.200102086. PMC 2150779. PMID 11470829.
• Jenkins SM, Kizhatil K, Kramarcy NR, Sen A, Sealock R, Bennett V (November 2001). "FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons". Journal of Cell Science. 114 (Pt 21): 3823–35. PMID 11719549.
• Jenkins SM, Bennett V (November 2001). "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments". The Journal of Cell Biology. 155 (5): 739–46. doi:10.1083/jcb.200109026. PMC 2150881. PMID 11724816.
• Charles P, Tait S, Faivre-Sarrailh C, Barbin G, Gunn-Moore F, Denisenko-Nehrbass N, Guennoc AM, Girault JA, Brophy PJ, Lubetzki C (February 2002). "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Current Biology. 12 (3): 217–20. doi:10.1016/S0960-9822(01)00680-7. PMID 11839274.
• Kizhatil K, Wu YX, Sen A, Bennett V (September 2002). "A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin". The Journal of Neuroscience. 22 (18): 7948–58. doi:10.1523/jneurosci.22-18-07948.2002. PMC 6758080. PMID 12223548.
• Gollan L, Salomon D, Salzer JL, Peles E (December 2003). "Caspr regulates the processing of contactin and inhibits its binding to neurofascin". The Journal of Cell Biology. 163 (6): 1213–8. doi:10.1083/jcb.200309147. PMC 2173730. PMID 14676309.