Melanoma inhibitory activity

Melanoma-derived growth regulatory protein is a protein that in humans is encoded by the MIA gene.[5][6][7]

MIA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HJD, 1I1J, 1K0X
Identifiers
Aliases	MIA, CD-RAP, Melanoma inhibitory activity, MIA SH3 domain containing
External IDs	OMIM: 601340 MGI: 109615 HomoloGene: 4763 GeneCards: MIA
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 40,771,648 bp[1] End 40,777,490 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 15.84 cM Start 27,179,742 bp[2] End 27,181,157 bp[2]
Gene ontology Molecular function • growth factor activity Cellular component • extracellular region • extracellular Biological process • cellular proliferation • regulation of receptor activity • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8190	12587
Ensembl	ENSG00000261857	ENSMUSG00000089661
UniProt	Q16674	Q61865
RefSeq (mRNA)	NM_006533 NM_001202553	NM_019394
RefSeq (protein)	NP_001189482 NP_006524	NP_062267
Location (UCSC)	Chr 19: 40.77 – 40.78 Mb	Chr 7: 27.18 – 27.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It is a marker for malignant melanoma.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000261857 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000089661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R, Bogdahn U (Nov 1994). "Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA". Cancer Res. 54 (21): 5695–701. PMID 7923218.
6. Koehler MR, Bosserhoff A, von Beust G, Bauer A, Blesch A, Buettner R, Schlegel J, Bogdahn U, Schmid M (Sep 1996). "Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH)". Genomics. 35 (1): 265–7. doi:10.1006/geno.1996.0352. PMID 8661134.
7. "Entrez Gene: MIA melanoma inhibitory activity".
8. Bosserhoff AK, Kaufmann M, Kaluza B, et al. (August 1997). "Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma". Cancer Res. 57 (15): 3149–53. PMID 9242442.

Further reading

• Bosserhoff AK, Hein R, Bogdahn U, Buettner R (1996). "Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA". J. Biol. Chem. 271 (1): 490–5. doi:10.1074/jbc.271.1.490. PMID 8550608.
• Stoll R, Renner C, Zweckstetter M, et al. (2001). "The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold". EMBO J. 20 (3): 340–9. doi:10.1093/emboj/20.3.340. PMC 133488. PMID 11157741.
• Lougheed JC, Holton JM, Alber T, et al. (2001). "Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5515–20. Bibcode:2001PNAS...98.5515L. doi:10.1073/pnas.091601698. PMC 33244. PMID 11331761.
• Lougheed JC, Domaille PJ, Handel TM (2002). "Solution structure and dynamics of melanoma inhibitory activity protein". J. Biomol. NMR. 22 (3): 211–23. doi:10.1023/A:1014961408029. PMID 11991352.
• Hau P, Apfel R, Wiese P, et al. (2002). "Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin". Anticancer Res. 22 (2A): 577–83. PMID 12014625.
• Hau P, Wise P, Bosserhoff AK, et al. (2002). "Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]". J. Invest. Dermatol. 119 (3): 562–9. doi:10.1046/j.1523-1747.2002.00501.x. PMID 12230496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Poser I, Golob M, Buettner R, Bosserhoff AK (2003). "Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype". Mol. Cell. Biol. 23 (8): 2991–8. doi:10.1128/MCB.23.8.2991-2998.2003. PMC 152547. PMID 12665595.
• Callejo SA, Marshall JC, Cools-Lartigue J, et al. (2005). "Macrophage-derived soluble factor enhances melanoma inhibitory activity expression by uveal melanoma cells in vitro". Melanoma Res. 14 (2): 91–5. doi:10.1097/00008390-200404000-00003. PMID 15057037.
• Marr DG, Poser I, Shellman YG, et al. (2005). "Ultraviolet radiation induces release of MIA: a new mechanism for UVR-induced progression of melanoma". Int. J. Oncol. 25 (1): 105–11. doi:10.3892/ijo.25.1.105. PMID 15201995.
• Poser I, Tatzel J, Kuphal S, Bosserhoff AK (2005). "Functional role of MIA in melanocytes and early development of melanoma". Oncogene. 23 (36): 6115–24. doi:10.1038/sj.onc.1207797. PMID 15208686.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Jachimczak P, Apfel R, Bosserhoff AK, et al. (2004). "Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques". Int. J. Cancer. 113 (1): 88–92. doi:10.1002/ijc.20549. PMID 15386421.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hau P, Ruemmele P, Kunz-Schughart LA, et al. (2005). "Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma". Oncol. Rep. 12 (6): 1355–64. doi:10.3892/or.12.6.1355. PMID 15547763.
• Tatzel J, Poser I, Schroeder J, Bosserhoff AK (2005). "Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes". Pigment Cell Res. 18 (2): 92–101. doi:10.1111/j.1600-0749.2005.00212.x. PMID 15760338.
• Aung PP, Oue N, Mitani Y, et al. (2006). "Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer". Oncogene. 25 (17): 2546–57. doi:10.1038/sj.onc.1209279. PMID 16331256.
• Cao MG, Auge JM, Molina R, et al. (2007). "Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma". Anticancer Res. 27 (1B): 595–9. PMID 17348447.