MOBKL1A

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.[4][5]

MOB1B
Identifiers
Aliases	MOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDs	OMIM: 609282 MGI: 1915723 HomoloGene: 61676 GeneCards: MOB1B
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 70,902,326 bp[1] End 71,022,449 bp[1]
Gene ontology Molecular function • kinase binding • GO:0001948 protein binding • kinase activator activity • metal ion binding Cellular component • cytoplasm • extracellular exosome • cell nucleus • nucleolus • cytosol Biological process • regulation of protein autophosphorylation • Hippo signaling pathway • positive regulation of phosphorylation • positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92597	68473
Ensembl	ENSG00000173542	n/a
UniProt	Q7L9L4	Q8BPB0
RefSeq (mRNA)	NM_001244766 NM_001244767 NM_173468	NM_026735
RefSeq (protein)	NP_001231695 NP_001231696 NP_775739	NP_081011
Location (UCSC)	Chr 4: 70.9 – 71.02 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.[4]

See also

• Hippo signaling pathway

References

1. GRCh38: Ensembl release 89: ENSG00000173542 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: MOB1".
5. Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi:10.1002/ijc.24878. PMID 19739119.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.