MIMETAS

Mimetas is a privately owned biotechnology company developing human organ-on-a-chip tissue models and products for drug development. The company also is involved in the testing of chemicals along with food and personalized medicine applications. The company is based in Leiden and Enschede, The Netherlands and in Rockville (MD), USA. Mimetas was founded in 2011 by Paul Vulto, Jos Joore, Bas Trietsch and Thomas Hankemeier.[1] The company is co-led by Joore and Vulto as Managing Directors.

Technology

Mimetas develops microfluidic tissue culture technology based on its proprietary OrganoPlate platform[2] that supports 3-dimensional tissue culture under continuous perfusion, with membrane-free co-culture in a standard 384-well plate format.[3] This renders the technology suitable for low- to high-throughput screening applications.[4] Mimetas develops a range of tissue- and disease models, including kidney toxicity and disease models,[5] iPSC-derived neuronal brain tissue models[4] and liver models.[3]

History

The original idea for the foundation of Mimetas was raised in 2010 by Vulto and Joore, who envisioned creating the tissue equivalent of a microarray for massive parallel testing of therapeutic compounds. The idea was based on meniscus pinning technology, originally developed by Vulto, during his affiliations with Silicon Biosystems (Bologna, IT), now part of the Menarini Group and the Institute for Microsystems Engineering (IMTEK) of the University of Freiburg (GER). Mimetas was established in close collaboration with the group of Thomas Hankemeier of the Leiden University, with essential contributions of Bas Trietsch who serves as Director of Research. Since its official incorporation in 2013, the company collaborates with a range of pharmaceutical companies on the development of tissue- and disease models, including Roche, BASF, GlaxoSmithKline, Pfizer, Abbvie, Janssen and Biogen.[6][7][8]

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References
  1. "Launch of organs-on-a-chip". Leiden University. Retrieved 4 March 2017.
  2. Willyard, Cassandra (2 Feb 2017). "Channeling chip power: Tissue chips are being put to the test by industry". Nature Medicine. 23 (2): 138–140. doi:10.1038/nm0217-138. PMID 28170380.
  3. Trietsch, Sebastiaan J.; Israëls, Guido D.; Joore, Jos; Hankemeier, Thomas; Vulto, Paul (26 Jul 2013). "Microfluidic titer plate for stratified 3D cell culture". Lab on a Chip. 13 (18): 3548–3554. doi:10.1039/C3LC50210D.
  4. Wevers, Nienke R.; Van Vught, Remko; Wilschut, Karlijn J.; Nicolas, Arnaud; Chiang, Chiwan; Lanz, Henriette L.; Trietsch, Sebastiaan J.; Joore, Jos; Vulto, Paul (9 Dec 2016). "High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform". Scientific Reports. 6: 38856. doi:10.1038/srep38856. PMC 5146966. PMID 27934939.
  5. Wilmer, Martijn J.; Ng, Chee Ping; Lanz, Henriëtte L.; Vulto, Paul; Suter-Dick, Laura; Masereeuw, Rosalinde (Feb 2016). "Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening". Trends in Biotechnology. 34 (2): 156–170. doi:10.1016/j.tibtech.2015.11.001. PMID 26708346. Retrieved 4 March 2017.
  6. "ADAPTED". Identifying new medicines to treat Alzheimer's Disease through greater understanding of the APOE gene. ADAPTED. Retrieved 4 March 2017.
  7. "Neuratect". Crack It. NC3Rs. Retrieved 4 March 2017.
  8. "NephroTube". Crack It. NC3Rs. Retrieved 4 March 2017.
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