MICAL1

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene.[5][6]

MICAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYL, 2CO8
Identifiers
Aliases	MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1
External IDs	OMIM: 607129 MGI: 2385847 HomoloGene: 11246 GeneCards: MICAL1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 109,444,062 bp[1] End 109,465,968 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B2 Start 41,476,314 bp[2] End 41,487,032 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • oxidoreductase activity • actin binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • FAD binding • Rab GTPase binding • GO:0001948 protein binding • metal ion binding • protein kinase binding • monooxygenase activity • NAD(P)H oxidase activity • actin filament binding Cellular component • cytoplasm • cytoskeleton • intermediate filament • hippocampal mossy fiber expansion • cytosol • midbody • intercellular bridge • cell membrane • actin cytoskeleton Biological process • negative regulation of protein phosphorylation • actin filament depolymerization • sulfur oxidation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of apoptotic process • oxidation-reduction process • cytoskeleton organization • signal transduction • regulation of regulated secretory pathway • blood coagulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64780	171580
Ensembl	ENSG00000135596	ENSMUSG00000019823
UniProt	Q8TDZ2	Q8VDP3
RefSeq (mRNA)	NM_022765 NM_001159291 NM_001286613	NM_001164433 NM_138315 NM_001358838 NM_001358839
RefSeq (protein)	NP_001152763 NP_001273542 NP_073602	NP_001157905 NP_612188 NP_001345767 NP_001345768
Location (UCSC)	Chr 6: 109.44 – 109.47 Mb	Chr 10: 41.48 – 41.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MICAL1 has been shown to interact with NEDD9[5] and RAB1A.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000135596 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019823 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). "MICAL, a novel CasL interacting molecule, associates with vimentin". J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID 11827972.
6. "Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1".
7. Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. United States. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN 0006-291X. PMID 12788069.

Further reading

• Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes". J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID 10808124.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID 12788069.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
• Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Jin X, Zhang J, Dai H, et al. (2007). "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain". Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID 17662518.