MARCH6

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.[5][6]

MARCHF6
Identifiers
Aliases	MARCHF6, DOA10, MARCH-VI, RNF176, TEB4, membrane associated ring-CH-type finger 6, MARCH6, FAME3
External IDs	OMIM: 613297 MGI: 2442773 HomoloGene: 4301 GeneCards: MARCHF6
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.2 Start 10,353,695 bp[1] End 10,440,388 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B2 Start 31,455,891 bp[2] End 31,531,053 bp[2]
Gene ontology Molecular function • enzyme binding • ubiquitin-specific protease binding • zinc ion binding • ubiquitin conjugating enzyme binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • ubiquitin-protein transferase activity • transferase activity • GO:0001948 protein binding Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • ER ubiquitin ligase complex • membrane • endoplasmic reticulum • endoplasmic reticulum membrane • endoplasmic reticulum quality control compartment Biological process • protein K48-linked ubiquitination • proteasomal protein catabolic process • ERAD pathway • protein ubiquitination • endoplasmic reticulum mannose trimming • ubiquitin-dependent ERAD pathway • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10299	223455
Ensembl	ENSG00000145495	ENSMUSG00000039100
UniProt	O60337	Q6ZQ89
RefSeq (mRNA)	NM_001270660 NM_001270661 NM_005885	NM_172606
RefSeq (protein)	NP_001257589 NP_001257590 NP_005876	NP_766194
Location (UCSC)	Chr 5: 10.35 – 10.44 Mb	Chr 15: 31.46 – 31.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Gene name error in Excel

Main article: Microsoft Excel § Conversion_problems

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH6 gene in Microsoft Excel.[7] This is due to Excel's autocorrect feature treating the text "MARCH6" as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.[8] The issue can be prevented by using an alias name (such as MARCHF6), prepending with an apostrophe ('), or preformatting the cell as text.

See also

• List of EC numbers (EC 3)

References

1. GRCh38: Ensembl release 89: ENSG00000145495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039100 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
6. "Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".
7. Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.
8. Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

Further reading

• Kreft SG, Wang L, Hochstrasser M (2006). "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)". J. Biol. Chem. 281 (8): 4646–53. doi:10.1074/jbc.M512215200. PMID 16373356.
• Hassink G, Kikkert M, van Voorden S, et al. (2005). "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum". Biochem. J. 388 (Pt 2): 647–55. doi:10.1042/BJ20041241. PMC 1138973. PMID 15673284.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Swanson R, Locher M, Hochstrasser M (2001). "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation". Genes Dev. 15 (20): 2660–74. doi:10.1101/gad.933301. PMC 312819. PMID 11641273.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

External links

• MARCH6 human gene location in the UCSC Genome Browser.
• MARCH6 human gene details in the UCSC Genome Browser.