List of SJS-inducing substances

This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome.

Name Other names
Allopurinol[1]
Amoxicillin[2]
Ampicillin[2]
Azithromycin [3] Zithromax
Barbiturates[4]
Carbamazepine[5]
Ciprofloxacin/levofloxacin/Gemifloxacin
Clozapine [6] Clozaril
Cotrimoxazole [7] Trimethoprim/sulfamethoxazole
Diclofenac[8]
Ethosuximide
Glutathione[9]
Ibuprofen[10]
Isotretinoin[11] Accutane
Lamotrigine[12] Lamictal
Modafinil[13] Provigil
Nevirapine
Norfloxacin[14]
Oseltamivir
Oxicams[7] Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam
Paracetamol[15][16] Acetaminophen, Panadol, Tylenol
Penicillins[5]
Phenytoin[5]
Rivoraxaban[17] Xarelto
Sitagliptin
Sulfonamides[2]
Tetracycline[2]
  1. Harr T, French LE (2012). Adverse Cutaneous Drug Eruptions. Chem Immunol Allergy. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. 97. pp. 149–166. doi:10.1159/000335627. ISBN 978-3-8055-9970-2. PMID 22613860.
  2. "Stevens Johnson Syndrome". WebMD.
  3. See, e.g.: Schultz, Laura (December 28, 2015). "Potential Zithromax Side Effects Include Stevens Johnson Syndrome". Top Class Actions, LLC. Archived from the original on December 29, 2015. Retrieved December 28, 2015. Several Zithromax lawsuits have been filed against Pfizer alleging that the drug maker failed to warn the medical community and the public about serious risks associated with taking the antibiotic.
  4. Mamishi, Setareh; Fattahi, Fatemeh; Pourpak, Zahra; Aghaee, Farzaneh Mirza; Moinfar, Zeinab; Mohammadi, Mahmoud; Ashrafi, Mahmoud; Moin, Mostafa (2009-11-01). "Severe cutaneous reactions caused by barbiturates in seven Iranian children". International Journal of Dermatology. 48 (11): 1254–1261. doi:10.1111/j.1365-4632.2007.03561.x. ISSN 1365-4632. PMID 20064188.
  5. Rehmus, Wingfield E (November 2013). "Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)". Merck Manual. Merck Sharp & Dohme Corp.
  6. Wu, Ming-Kung; Chung, Weilun; Wu, Ching-Kuan; Tseng, Ping-Tao (2015-01-01). "The severe complication of Stevens-Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report". Neuropsychiatric Disease and Treatment. 11: 1039–1041. doi:10.2147/NDT.S79327. ISSN 1176-6328. PMC 4399514. PMID 25914536.
  7. Mockenhaupt, Maja; Viboud, Cecile; Dunant, Ariane; Naldi, Luigi; Halevy, Sima; Bavinck, Jan Nico Bouwes; Sidoroff, Alexis; Schneck, Jürgen; Roujeau, Jean-Claude; Flahault, Antoine (2008-01-01). "Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Assessment of Medication Risks with Emphasis on Recently Marketed Drugs. The EuroSCAR-Study". Journal of Investigative Dermatology. 128 (1): 35–44. doi:10.1038/sj.jid.5701033. ISSN 0022-202X. PMID 17805350.
  8. Roujeau, J.-C., Kelly, J. P., Naldi, L., Rzany, B., Stern, R. S., Anderson, T., Auquier, A., Bastuji-Garin, S., Correia, O., Locati, F., Mockenhaupt, M., Paoletti, C., Shapiro, S., Shear, N., Schopf, E., Kaufman, D. W. (1995). "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis". N Engl J Med. 333 (1): 1600–1607. doi:10.1056/NEJM199512143332404. PMID 7477195.CS1 maint: multiple names: authors list (link)
  9. "Safety of off label use of Glutathione Injection" (PDF).
  10. Raksha MP, Marfatia YS (2008). "Clinical study of cutaneous drug eruptions in 200 patients". Indian J Dermatol Venereol Leprol. 74 (1): 80. doi:10.4103/0378-6323.38431. PMID 18193504.
  11. Medsafe Data Sheet Archived 2007-09-28 at the Wayback Machine March 8, 2005. Accessed April 26, 2007.
  12. "LAMICTAL PRESCRIBING INFORMATION" (PDF). GlaxoSmithKline. Archived from the original (PDF) on 2006-09-13. Retrieved 2009-12-17.
  13. "PROVIGIL PRESCRIBING INFORMATION" (PDF). Cephalon, Inc. Archived from the original (PDF) on 2015-05-01.
  14. "Norfloxacin" (PDF). Davis. 2017. Retrieved March 24, 2017.
  15. Khawaja A, Shahab A, Hussain SA (May 2012). "Acetaminophen-induced Steven Johnson syndrome-toxic epidermal necrolysis overlap". J Pak Med Assoc. 62 (5): 524–7. PMID 22755330.
  16. "Stevens-Jonhson syndrome after acetaminophen ingestion, confirmed by challenge test in an eleven-year-old patient". the Journal: Allergologia et Immunopathologia.
  17. "Scientific conclusions and grounds for the variation to the terms of the marketing authorisation(s)" (PDF) (data sheet). European Medicines Agency. 6 April 2017.
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