LYVE1

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor.[5] In humans it is encoded by the LYVE1 gene.[6]

LYVE1
Identifiers
Aliases	LYVE1, CRSBP-1, HAR, LYVE-1, XLKD1, lymphatic vessel endothelial hyaluronan receptor 1
External IDs	OMIM: 605702 MGI: 2136348 HomoloGene: 4868 GeneCards: LYVE1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 10,556,966 bp[1] End 10,611,689 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 110,850,607 bp[2] End 110,863,239 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • hyaluronic acid binding • transmembrane signaling receptor activity • receptor activity • signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • extracellular exosome • cell periphery Biological process • movement of cell or subcellular component • hyaluronan catabolic process • anatomical structure morphogenesis • cell adhesion • response to wounding • glycosaminoglycan catabolic process • cell-matrix adhesion • signal transduction • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10894	114332
Ensembl	ENSG00000133800	ENSMUSG00000030787
UniProt	Q9Y5Y7	Q8BHC0
RefSeq (mRNA)	NM_006691	NM_053247
RefSeq (protein)	NP_006682	NP_444477
Location (UCSC)	Chr 11: 10.56 – 10.61 Mb	Chr 7: 110.85 – 110.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

LYVE1 is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.[6] LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, allowing for the isolation of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role.

Expression of LYVE1 not restricted to lymph vessels but is also observed in normal liver blood sinusoids [7], and embryonic blood vessels [8].

LYVE1 expression is also observed in subset of macrophages.[9] [10] LYVE1 positive macrophages in the meninges of rats are both lymphatic, as well as, alymphatic.[11] In brain dura, the LYVE1+ macrophages were predominantly pleomorphic in morphology, while the cells in the spinal cord were pleomorphic in the cervical dura, while in the thoracal dura the cells were mainly round in morphology. The cells in brain dura were associated with collagen network in meninges, and some nonlymphatic LYVE1+ macrophages contained intracellular collagen. The exact function of these cells is yet unknown.

References

1. GRCh38: Ensembl release 89: ENSG00000133800 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, et al. (February 1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". The Journal of Cell Biology. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
6. "LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]".
7. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK (November 2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Research. 61 (22): 8079–84. PMID 11719431.
8. Gordon EJ, Gale NW, Harvey NL (July 2008). "Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels". Developmental Dynamics. 237 (7): 1901–9. doi:10.1002/dvdy.21605. PMID 18570254.
9. Lee HW, Qin YX, Kim YM, Park EY, Hwang JS, Huo GH, et al. (February 2011). "Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney". Cell and Tissue Research. 343 (2): 429–44. doi:10.1007/s00441-010-1098-x. PMID 21181199.
10. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA (April 2007). "Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing". The American Journal of Pathology. 170 (4): 1178–91. doi:10.2353/ajpath.2007.060018. PMC 1829452. PMID 17392158.
11. Brezovakova V, Jadhav S (January 2020). "Identification of Lyve-1 positive macrophages as resident cells in meninges of rats". The Journal of Comparative Neurology. doi:10.1002/cne.24870. PMID 32003471.

Further reading

• Jackson DG (January 2003). "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1". Trends in Cardiovascular Medicine. 13 (1): 1–7. doi:10.1016/S1050-1738(02)00189-5. PMID 12554094.
• Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, et al. (February 1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". The Journal of Cell Biology. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
• Cunnick GH, Jiang WG, Gomez KF, Mansel RE (November 2001). "Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model". Biochemical and Biophysical Research Communications. 288 (4): 1043–6. doi:10.1006/bbrc.2001.5869. PMID 11689016.
• Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK (November 2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Research. 61 (22): 8079–84. PMID 11719431.
• Cursiefen C, Schlötzer-Schrehardt U, Küchle M, Sorokin L, Breiteneder-Geleff S, Alitalo K, Jackson D (July 2002). "Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin". Investigative Ophthalmology & Visual Science. 43 (7): 2127–35. PMID 12091407.
• Huang SS, Tang FM, Huang YH, Liu IH, Hsu SC, Chen ST, Huang JS (October 2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1". The Journal of Biological Chemistry. 278 (44): 43855–69. doi:10.1074/jbc.M306411200. PMID 12912978.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nguyen VA, Kutzner H, Fürhapter C, Tzankov A, Sepp N (February 2006). "Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence". Modern Pathology. 19 (2): 291–8. doi:10.1038/modpathol.3800537. PMID 16424896.
• Gu B, Alexander JS, Gu Y, Zhang Y, Lewis DF, Wang Y (2007). "Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta". Lymphatic Research and Biology. 4 (1): 11–7. doi:10.1089/lrb.2006.4.11. PMC 3072054. PMID 16569201.
• Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, Schwartz M, et al. (December 2006). "A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis". Gastroenterology. 131 (6): 1758–67. doi:10.1053/j.gastro.2006.09.014. PMID 17087938.