LPIN1

Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.[5][6][7][8]

LPIN1
Identifiers
Aliases	LPIN1, PAP1, lipin 1
External IDs	OMIM: 605518 MGI: 1891340 HomoloGene: 9266 GeneCards: LPIN1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 11,677,595 bp[1] End 11,827,409 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 7.9 cM Start 16,535,669 bp[2] End 16,646,966 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • hydrolase activity • phosphatidate phosphatase activity • molecular function Cellular component • cytoplasm • cytosol • nuclear membrane • nuclear envelope • endoplasmic reticulum membrane • membrane • nucleoplasm • mitochondrial outer membrane • endoplasmic reticulum • cell nucleus Biological process • fatty acid catabolic process • regulation of transcription, DNA-templated • lipid metabolism • regulation of transcription from RNA polymerase II promoter • phosphatidylethanolamine biosynthetic process • transcription, DNA-templated • fatty acid metabolic process • mitotic nuclear envelope disassembly • animal organ regeneration • cellular response to insulin stimulus • triglyceride biosynthetic process • phosphatidylcholine biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • triglyceride mobilization • dephosphorylation • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23175	14245
Ensembl	ENSG00000134324	ENSMUSG00000020593
UniProt	Q14693	Q91ZP3
RefSeq (mRNA)	NM_001261427 NM_001261428 NM_001261429 NM_145693 NM_001349199 NM_001349200 NM_001349201 NM_001349202 NM_001349203 NM_001349204 NM_001349205 NM_001349206 NM_001349207 NM_001349208	NM_001130412 NM_015763 NM_172950 NM_001355598
RefSeq (protein)	NP_001248356 NP_001248357 NP_663731 NP_001336128 NP_001336129 NP_001336130 NP_001336131 NP_001336132 NP_001336133 NP_001336134 NP_001336135 NP_001336136 NP_001336137	NP_001123884 NP_056578 NP_766538 NP_001342527
Location (UCSC)	Chr 2: 11.68 – 11.83 Mb	Chr 12: 16.54 – 16.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Lipin-1 has phosphatidate phosphatase activity.[9][10][11] The nuclear localization of Lipin 1 is regulated by the mammalian Target Of Rapamycin protein kinase and links mTORC1 activity to the regulation of Sterol regulatory element-binding proteins (SREBP)-dependent gene transcription.[12][13][14]

Clinical significance

This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.[8][12]

References

1. GRCh38: Ensembl release 89: ENSG00000134324 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020593 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Péterfy M, Phan J, Xu P, Reue K (January 2001). "Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin". Nature Genetics. 27 (1): 121–4. doi:10.1038/83685. PMID 11138012.
6. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
7. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, Kelly DP (September 2006). "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway". Cell Metabolism. 4 (3): 199–210. doi:10.1016/j.cmet.2006.08.005. PMID 16950137.
8. "Entrez Gene: LPIN1 lipin 1".
9. Han GS, Wu WI, Carman GM (April 2006). "The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme". The Journal of Biological Chemistry. 281 (14): 9210–8. doi:10.1074/jbc.M600425200. PMC 1424669. PMID 16467296.
10. Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K (February 2007). "Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns". The Journal of Biological Chemistry. 282 (6): 3450–7. doi:10.1074/jbc.M610745200. PMID 17158099.
11. Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC (January 2007). "Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1". The Journal of Biological Chemistry. 282 (1): 277–86. doi:10.1074/jbc.M609537200. PMID 17105729.
12. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM (August 2011). "mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway". Cell. 146 (3): 408–20. doi:10.1016/j.cell.2011.06.034. PMC 3336367. PMID 21816276.
13. Kennedy BK, Lamming DW (June 2016). "The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging". Cell Metabolism. 23 (6): 990–1003. doi:10.1016/j.cmet.2016.05.009. PMC 4910876. PMID 27304501.
14. Laplante M, Sabatini DM (April 2013). "Regulation of mTORC1 and its impact on gene expression at a glance". Journal of Cell Science. 126 (Pt 8): 1713–9. doi:10.1242/jcs.125773. PMC 3678406. PMID 23641065.

Further reading

• Péterfy M, Phan J, Oswell GM, Xu P, Reue K (December 1999). "Genetic, physical, and transcript map of the fld region on mouse chromosome 12". Genomics. 62 (3): 436–44. doi:10.1006/geno.1999.6023. PMID 10644441.
• Reue K, Xu P, Wang XP, Slavin BG (July 2000). "Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene". Journal of Lipid Research. 41 (7): 1067–76. PMID 10884287.
• Huffman TA, Mothe-Satney I, Lawrence JC (January 2002). "Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin". Proceedings of the National Academy of Sciences of the United States of America. 99 (2): 1047–52. doi:10.1073/pnas.022634399. PMC 117427. PMID 11792863.
• Cao H, Hegele RA (2003). "Identification of single-nucleotide polymorphisms in the human LPIN1 gene". Journal of Human Genetics. 47 (7): 370–2. doi:10.1007/s100380200052. PMID 12111372.
• Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L (February 2006). "Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism". Human Molecular Genetics. 15 (3): 377–86. doi:10.1093/hmg/ddi448. PMID 16357106.
• Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ, McGehee RE, Reue K, Kern PA (October 2006). "Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation". Diabetes. 55 (10): 2811–8. doi:10.2337/db05-1688. PMID 17003347.
• van Harmelen V, Rydén M, Sjölin E, Hoffstedt J (January 2007). "A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression". Journal of Lipid Research. 48 (1): 201–6. doi:10.1194/jlr.M600272-JLR200. PMID 17035674.
• Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC (January 2007). "Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1". The Journal of Biological Chemistry. 282 (1): 277–86. doi:10.1074/jbc.M609537200. PMID 17105729.
• Croce MA, Eagon JC, LaRiviere LL, Korenblat KM, Klein S, Finck BN (September 2007). "Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss". Diabetes. 56 (9): 2395–9. doi:10.2337/db07-0480. PMID 17563064.