LETM1-like protein family
LETM1-like is a family of evolutionarily related proteins.
LETM1 | |||||||||
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Identifiers | |||||||||
Symbol | LETM1 | ||||||||
Pfam | PF07766 | ||||||||
InterPro | IPR011685 | ||||||||
TCDB | 8.A.20 | ||||||||
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This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.[1] A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster,[2] suggesting that this may be a group of mitochondrial proteins.
Examples
Human gene encoding members of this family include:
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gollark: <@543131534685765673> 2fd575c5d947cae5b79f286a08991fab04c65636c6cf6a3b7218f0858740b27a09d5d31b1d65c3ab7b356b134298ef9c13a475eb4e00b81d4dfdc8228150969e
gollark: 565b06ade1fa5f9cb79d026f977d2bb9492605a28e3fa9c968a830d6bdae974b2d46e6ac694abade7567c8e830db2956189a237b24bfe4821df5c984e9ff8497
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References
- Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A (September 1999). "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics. 60 (2): 218–25. doi:10.1006/geno.1999.5881. PMID 10486213.
- Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P (February 1999). "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database". Mol. Gen. Genet. 261 (1): 64–70. doi:10.1007/s004380050942. PMID 10071211.
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