LETM1-like protein family
LETM1-like is a family of evolutionarily related proteins.
| LETM1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LETM1 | ||||||||
| Pfam | PF07766 | ||||||||
| InterPro | IPR011685 | ||||||||
| TCDB | 8.A.20 | ||||||||
| |||||||||
This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.[1] A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster,[2] suggesting that this may be a group of mitochondrial proteins.
Examples
Human gene encoding members of this family include:
gollark: Arguably quite a lot are. Depending on things, you may end up suffering more overhead trying to split up work, merge your parts back together, maintain multiple copies of things, communicate, and that sort of thing, than you would just doing all of it yoursel.
gollark: Nobody knows. It's just abstract philosophy right now.
gollark: Use an existing image editor and screen sharing thing at the same time?
gollark: Given that nobody is really sure how consciousness works (or, well, lots of people seem to be sure, but they disagree with each other and there isn't really empirical evidence).
gollark: As of now, it is not possible to actually check this.
References
- Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A (September 1999). "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics. 60 (2): 218–25. doi:10.1006/geno.1999.5881. PMID 10486213.
- Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P (February 1999). "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database". Mol. Gen. Genet. 261 (1): 64–70. doi:10.1007/s004380050942. PMID 10071211.
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