KPNA5

Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene.[3]

KPNA5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4U2X
Identifiers
Aliases	KPNA5, IPOA6, SRP6, karyopherin subunit alpha 5
External IDs	OMIM: 604545 HomoloGene: 128489 GeneCards: KPNA5
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 116,681,187 bp[1] End 116,741,866 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nuclear localization sequence binding • GO:0001948 protein binding • nuclear import signal receptor activity Cellular component • nuclear pore • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • protein transport • modulation by virus of host process • NLS-bearing protein import into nucleus • protein import into nucleus • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3841	n/a
Ensembl	ENSG00000196911	n/a
UniProt	O15131 Q5TD90	n/a
RefSeq (mRNA)	NM_002269	n/a
RefSeq (protein)	NP_002260 NP_001353233 NP_001353234 NP_001353235 NP_001353236 NP_001353237 NP_001353238 NP_001353239	n/a
Location (UCSC)	Chr 6: 116.68 – 116.74 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs).

KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus[4]

References

1. GRCh38: Ensembl release 89: ENSG00000196911 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Jan 1998). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Lett. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085.
4. "Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)".

Further reading

• Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader". Front. Biosci. 2 (4): d578–87. doi:10.2741/A213. PMID 9366553.
• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. doi:10.1007/BF03401911. PMC 2230352. PMID 9562972.
• Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. doi:10.1073/pnas.89.14.6580. PMC 49545. PMID 1631159.
• Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6. doi:10.1089/aid.1991.7.303. PMID 2064827.
• Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase". Cell. 83 (4): 569–76. doi:10.1016/0092-8674(95)90097-7. PMID 7585960.
• Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection". J. Virol. 69 (6): 3949–54. doi:10.1128/JVI.69.6.3949-3954.1995. PMC 189124. PMID 7745752.
• Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator". Cell. 80 (3): 379–88. doi:10.1016/0092-8674(95)90488-3. PMID 7859280.
• von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. doi:10.1073/pnas.91.15.6992. PMC 44324. PMID 8041734.
• Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. doi:10.1073/pnas.91.15.7311. PMC 44389. PMID 8041786.
• Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature. 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
• Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention". Mol. Med. 1 (2): 217–30. doi:10.1007/BF03401569. PMC 2229944. PMID 8529100.
• Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. doi:10.1128/JVI.70.2.1027-1032.1996. PMC 189908. PMID 8551560.
• Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.
• Sato A, Yoshimoto J, Isaka Y, et al. (1996). "Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion". Virology. 220 (1): 208–12. doi:10.1006/viro.1996.0302. PMID 8659115.
• Popov S, Dubrovsky L, Lee MA, et al. (1996). "Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11859–64. doi:10.1073/pnas.93.21.11859. PMC 38149. PMID 8876228.
• Freed EO, Englund G, Maldarelli F, Martin MA (1997). "Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection". Cell. 88 (2): 171–3, discussion 173–4. doi:10.1016/S0092-8674(00)81836-X. PMID 9008157.
• Gallay P, Hope T, Chin D, Trono D (1997). "HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. doi:10.1073/pnas.94.18.9825. PMC 23276. PMID 9275210.
• Besançon F, Just J, Bourgeade MF, et al. (1997). "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". J. Interferon Cytokine Res. 17 (8): 461–7. doi:10.1089/jir.1997.17.461. PMID 9282826.