Isomorph (gene)

After Muller's classification was described as an isomorph, or gene mutation that expresses a nonsense point mutant with expression identical to the original allele.

Therefore, in respect of the relationships between the original and mutated genes it is difficult to ascertain the effects of dominanceness or/and recessiveness.[1][2] [3]

Muller’s classification of mutant alleles
Category Alternative function
Wild type Referent gene expression, normal expression of parent allele
Amorph Dysfunctional, with null expression
Hypomorph Reduced or partially reduced gene activity
Hypermorph Increased or partially increased parent gene activity
Neomorph Novel function, compared to the new property
Antimorph Interfering with gene activity
Isomorph Expression identical to the original (parent) allele, mostly resulting from silent point mutations

See also

References

  1. Lawrence E., ed. (1999). Henderson's Dictionary of biological terms. London: Longman Group Ltd. ISBN 0-582-22708-9.
  2. Rieger R. Michaelis A., Green M. M. (1976). Glossary of genetics and cytogenetics: Classical and molecular. Berlin - Heidelberg - New York: Springer-Verlag. ISBN 3-540-07668-9.CS1 maint: uses authors parameter (link)
  3. http://www.its.caltech.edu/~bi190/SG4.pdf
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