IQ calmodulin-binding motif

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b7t, 1br1, 1br2, 1br4, 1d0x, 1d0y, 1d0z, 1d1a,1d1b,1d1c, 1dfk, 1dfl, 1fmv, 1fmw, 1jwy, 1jx2, 1kk7, 1kk8,1kqm, 1kwo, 1l2o, 1lkx, 1lvk, 1mma, 1mmd, 1mmg, 1mmn,1mnd, 1mne, 1oe9, 1qvi, 1s5g, 1scm, 1sr6, 1vom, 1w7i,1w7j, 1wdc, 2mys

IQ calmodulin-binding motif
	Structure of the regulatory domain of scallop myosin at 2 A resolution.[1]
Identifiers
Symbol	IQ
Pfam	PF00612
InterPro	IPR000048
SMART	SM00015
PROSITE	PS50096
SCOPe	1wdc / SUPFAM
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b7t, 1br1, 1br2, 1br4, 1d0x, 1d0y, 1d0z, 1d1a,1d1b,1d1c, 1dfk, 1dfl, 1fmv, 1fmw, 1jwy, 1jx2, 1kk7, 1kk8,1kqm, 1kwo, 1l2o, 1lkx, 1lvk, 1mma, 1mmd, 1mmg, 1mmn,1mnd, 1mne, 1oe9, 1qvi, 1s5g, 1scm, 1sr6, 1vom, 1w7i,1w7j, 1wdc, 2mys

The IQ calmodulin-binding motif is an amino acid sequence motif containing the following sequence:

[FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY]

The term "IQ" refers to the first two amino acids of the motif: isoleucine (commonly) and glutamine (invariably).

Function

Calmodulin (CaM) is recognized as a major calcium (Ca²⁺) sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca²⁺-independent binding and two related motifs for Ca²⁺-dependent binding, termed 1-14 and 1-5-10 based on the position of conserved hydrophobic residues.[2]

Example

The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca²⁺ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca²⁺-binding site is a novel EF hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains, accounting for the requirement of all three chains for Ca²⁺binding and regulation in the intact myosin molecule.[3]

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gollark: I didn't say they were.

gollark: RocketRace probably didn't need to leave and it was somewhat <:bees:724389994663247974> of him to do so, I suppose.

gollark: And yes, it's stupid, but you can't stop people doing stupid things and should respect their wishes regarding stuff about them even if their wishes are stupid.

gollark: I don't think so. But IIRC he said he *might* continue to, although we resolved that in the conference.

References

Houdusse A, Cohen C (January 1996). "Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation". Structure. 4 (1): 21–32. doi:10.1016/S0969-2126(96)00006-8. PMID 8805510.
Rhoads AR, Friedberg F (April 1997). "Sequence motifs for calmodulin recognition". FASEB J. 11 (5): 331–40. doi:10.1096/fasebj.11.5.9141499. PMID 9141499.
Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Györgyi AG, Cohen C (March 1994). "Structure of the regulatory domain of scallop myosin at 2.8 A resolution". Nature. 368 (6469): 306–12. doi:10.1038/368306a0. PMID 8127365.

This article incorporates text from the public domain Pfam and InterPro: IPR000048

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[pmid8805510-1] Houdusse A, Cohen C (January 1996). "Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation". Structure. 4 (1): 21–32. doi:10.1016/S0969-2126(96)00006-8. PMID 8805510.

[pmid9141499-2] Rhoads AR, Friedberg F (April 1997). "Sequence motifs for calmodulin recognition". FASEB J. 11 (5): 331–40. doi:10.1096/fasebj.11.5.9141499. PMID 9141499.

[pmid8127365-3] Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Györgyi AG, Cohen C (March 1994). "Structure of the regulatory domain of scallop myosin at 2.8 A resolution". Nature. 368 (6469): 306–12. doi:10.1038/368306a0. PMID 8127365.