INPP4B

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.[5]

INPP4B
Identifiers
AliasesINPP4B, inositol polyphosphate-4-phosphatase type II B
External IDsOMIM: 607494 MGI: 2158925 HomoloGene: 20832 GeneCards: INPP4B
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q31.21Start142,023,160 bp[1]
End142,847,432 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8821

234515

Ensembl

ENSG00000109452

ENSMUSG00000037940

UniProt

O15327
Q9BS68

Q6P1Y8

RefSeq (mRNA)

NM_001101669
NM_003866
NM_001331040

NM_001024617
NM_001297591
NM_001297593
NM_001297596

RefSeq (protein)

NP_001095139
NP_001317969
NP_003857

NP_001019788
NP_001284520
NP_001284522
NP_001284525

Location (UCSC)Chr 4: 142.02 – 142.85 MbChr 8: 81.34 – 82.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines [6]. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000109452 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037940 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa". Retrieved 2012-07-24.
  6. Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (October 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications. 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMC 4578723. PMID 24070612.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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