Hydrophosphonylation

In chemistry hydrophosphonylation refers to any reaction where addition across a double bond generates a phosphonate (RP(O)(OR')2) group.[1] Examples include the Kabachnik–Fields reaction, where a dialkylphosphite reacts across an imine to form an aminophosphonate. The reaction is catalyzed by bases and is subject to organocatalysis.[2][3] Important compounds generated by this reaction include the common herbicide glyphosate.

Hydrophosphonylation reactions
gollark: What question do you want me to ask, specifically?
gollark: Or GPT-2, which I can actually get access to.
gollark: What if we ask GPT-3?
gollark: What if we ask that octahedral writer who came up with those random grammar rules in English last century?
gollark: What if we ask someone missing, what is it, Wernicke's area, which is the bit of the brain doing language processing?

See also

References
  1. Pudovik, A. N.; Konovalova, I. V. (1979). "Addition Reactions of Esters of Phosphorus(III) Acids with Unsaturated Systems". Synthesis. 1979 (02): 81–96. doi:10.1055/s-1979-28566.
  2. Pedro Merino, Eugenia Marqués‐López, Raquel P. Herrera (2008). "Catalytic Enantioselective Hydrophosphonylation of Aldehydes and Imines". Advanced Synthesis and Catalysis. 350: 1195–1208. doi:10.1002/adsc.200800131. hdl:10261/114023.CS1 maint: uses authors parameter (link)
  3. Shaoquan Lin, Yasunari Otsuka, Liang Yin, Naoya Kumagai, Masakatsu Shibasaki (2017). "Catalytic Enantioselective Addition of Diethyl Phosphite to N-Thiophosphinoyl Ketimines: Preparation of (R)-Diethyl (1-Amino-1-phenylethyl)phosphonate". Org. Synth. 94: 313–331. doi:10.15227/orgsyn.094.0313.CS1 maint: uses authors parameter (link)
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