Hearing Health Foundation

Hearing Health Foundation (HHF) is a 501c3 nonprofit organization whose mission is to prevent and cure hearing loss and tinnitus through groundbreaking research, and promote hearing health. In 2011, the Deafness Research Foundation changed its name to Hearing Health Foundation.[3]

Hearing Health Foundation
Founded1958[1]
FounderCollette Ramsey-Baker
TypePublic Charity- 501(c)(3)
FocusTo prevent and cure hearing loss and tinnitus through groundbreaking research and to promote hearing health.
Location
Area served
United States
MethodPrivate Donations
Key people
John Dillard(Chairman)
Paul E. Orlin (Vice Chair)
Elizabeth Keithley, Ph.D. (Chair Emerita)
Robert Boucai (Treasurer)
Michael Nolan (Secretary)
Timothy Higdon (CEO)
Employees
6
WebsiteHearing Health Foundation
Formerly called
Deafness Research Foundation (1958–2011)[2]

HHF was founded as the Deafness Research Foundation in 1958, by Collette Ramsey Baker, a woman who lived with a substantial hearing loss. Since then, HHF has worked to provide funding for basic, clinical and translational research in hearing and balance science, and worked towards research and treatments for people with hearing loss, tinnitus, and other hearing conditions. This includes funding research that led to the development of cochlear implants and treatments for otosclerosis (abnormal bone growth in the ear) and ear infections. In the 1990s HHF advocated in Washington, D.C., for universal neonatal hearing screening legislation, to detect hearing loss at birth.

The primary aims of the foundation are to promote awareness of hearing health and the prevention of noise induced hearing loss, provide seed money to researchers focused on hearing and balance science through grants, and to find better therapies and cures for hearing loss and tinnitus through the Hearing Restoration Project (HRP) and Emerging Research Grants (ERG) programs.

History

The Deafness Research Foundation was founded by Collette Ramsey-Baker on February 1, 1958.[4] Born in Waverly, Tennessee, Collette lived with substantial hearing loss for many years before she had her hearing completely restored at age 35, with an early fenestration operation. She then founded the Deafness Research Foundation (DRF). A recurrent model for the renowned painter Howard Chandler Christy and an avid golfer, she received letters of commendation from US Presidents Herbert Hoover and Dwight Eisenhower, Helen Keller and Cardinal Francis Spellman.[5]

In 1960, DRF and the American Academy of Otolaryngology created the National Temporal Bone Banks Program, to collect and study the human temporal bone, and to encourage temporal bone donation. In 1992 the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry was founded as a nonprofit organization by the National Institute of Deafness and other Communication Disorders (NIDCD) of the National Institutes of Health to continue and expand on the activities of the former National Temporal Bone Banks Program.[6]

By 1972, the DRF was funding research on cochlear implants, with later grants in single channel to multi-channel implants, speech perception among cochlear implant users, and implants in children. Substantial research and significant contribution in the prevention and treatment of middle ear infection was made by researchers who were awarded grants. In 1977 the DRF funded research in outer ear hair cell motility that led to a new method for measuring the health of a newborn's ear, and began funding research to understand how sensory cells transmit sounds from the world to the brain.

The DRF funded research led, in 1987, to the discovery of spontaneous regeneration of hair cells in chickens, thus igniting the field of hair cell regeneration in humans. Research on the regrowth of cochlea cells may lead to medical treatments that restore hearing. Unlike birds and reptiles, humans and other mammals are normally unable to regrow the cells of the inner ear that convert sound into neural signals when those cells are damaged by age or disease.[7]

In 1989 the DRF funded Meniere's Disease Study Center for improved evaluation and better treatments of Ménière's disease.

In celebration of the 50th Anniversary, the DRF rang the opening bell at the New York Stock Exchange in 2008.[8]

The organization decided to change its name from The Deafness Research Foundation to Hearing Health Foundation to better communicate the foundation's mission to prevent and cure hearing loss and tinnitus through groundbreaking research, and promote hearing health. On September 14, 2011 the Chair of the Board, Clifford P. Tallman, Jr., announced the name change of the DRF to Hearing Health Foundation and presented a new research consortium, the Hearing Restoration Project.[3]

Research programs

Emerging Research Grants

Through its Emerging Research Grants (ERG), HHF provides seed money to researchers, particularly those whose work is focused on areas of otology that have been under-researched and under-represented through traditional funding mechanisms. Through ERG, HHF has awarded over millions of dollars through more than 2,200 scientific research grants to researchers.

Many of HHF's grantees have also received federal grants. Former grantees make up 20 percent of recipients of the Association for Research in Otolaryngology Award of Merit. Many researchers we funded go on to obtain National Institutes of Health (NIH) funding for their work.

Hearing Health Foundation supports research in the following areas:

Hearing Restoration Project

The Hearing Restoration Project is a consortium of 14-senior scientists working collaboratively on scientific research towards inner ear hair cell regeneration and accelerate the time frame for developing a cure for hearing loss. The HRP brings together researchers from Harvard University, Stanford University, the University of Washington and elsewhere with the goal of researching and developing a genuine cure for most forms of acquired hearing loss by regenerating the inner ear hair cells that enable hearing.

Hearing Restoration Project Consortium
  • Peter Bar-Gillespie Ph.D. (Scientific Director): Professor of Otolaryngology, Oregon Health & Science University
  • Seth Ament, Ph.D., Assistant Professor, Psychiatry, Faculty Member, Institute for Genome Sciences, University of Maryland School of Medicine
  • John Brigande, Ph.D., Associate Professor of Otolaryngology, Oregon Health & Science University
  • Alain Dabdoub, Ph.D., Scientist, Sunnybrook Research Institute
  • Albert Edge, Ph.D., Professor of Otolaryngology, Massachusetts Eye and Ear Infirmary
  • Andy Groves, Ph.D., Professor of Neuroscience, Baylor College of Medicine
  • Stefan Heller, Ph.D., Professor of Otolaryngology–Head and Neck Surgery, Stanford University
  • Ronna Hertzano, M.D., Ph.D., Assistant Professor of Otorhinolaryngology, Head & Neck Surgery, University of Maryland School of Medicine
  • Michael Lovett, Ph.D., Professor and Chair of Systems Biology, National Heart & Lung Institute, Imperial College London
  • Tatjana Piotrowski, Ph.D., Associate Investigator, Stowers Institute for Medical Research
  • David Raible, Ph.D., Professor of Biological Structure, University of Washington
  • Yehoash Raphael, Ph.D., R. Jamison and Betty Williams Professor of Otolaryngology, University of Michigan
  • Edwin Rubel, Ph.D., Virginia Merrill Bloedel Chair of Hearing Science, Virginia Merrill Bloedel Hearing Research Center, University of Washington
  • Neil Segil, Ph.D., Research Associate Professor, Broad/CIRM Center for Regenerative Medicine and Stem Cell Biology, University of Southern California
  • Jennifer S. Stone, Ph.D., Research Associate Professor of Otolaryngology–Head and Neck Surgery, University of Washington
  • Mark Warchol, Ph.D., Professor of Otolaryngology, Washington University School of Medicine[9]

Strategic research plan
  • Phase 1 – Discovery research: Scientists have identified various pathways for hair cell regeneration. Since there are many potential gene targets, they continually utilize bioinformatics methods to winnow down and determine which are most relevant. Researchers have shown in the mouse neighboring supporting cells remain after deafening.
  • Phase 2 – Recent technological advances have enabled researchers to examine single hair cells rather than entire clusters. This aids in the study of gene expression immediately after a single hair cell is damaged. Researchers are examining early events that occur in the hair cells of zebrafish and chicks, but not in mice. The genes not undergoing the same expression in the mouse as in the other two animal models will be targets for manipulation.
  • Phase 3 – Develop treatments: Experimental models from Phase 2 will be used to screen for possible treatments.

Cell regeneration summit and webinars
  • In 2011, Hearing Health Foundation hosted a public-focused health conference bringing together leaders in the field of cell regeneration research in the ear to discuss current research and potential therapies to restore hearing as part of the HRP.[10]
  • On May 21, 2015, Hearing Health Foundation hosted at live-video research briefing to provide updates on research programs and progress. Dr. Peter Barr-Gillespie, Scientific Director, Hearing Restoration Project presented on the Hearing Restoration Project.

Prevention and education

Hearing Health Foundation publishes the Hearing Health magazine, Hearing Health E-News, and a weekly blog to supply information about current research and technologies related to hearing loss, tinnitus, and other hearing conditions, as well as provides general information about the Foundation's work, education, and prevention efforts.

In 2011 Hearing Health Foundation demonstrated how sound travels and educated approximately 18,000 children at Nickelodeon's "Day of Play" at the Mall in Washington, DC.[11]

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References
  1. "Hearing Health Foundation History". Hearing Health Foundation. Retrieved 22 August 2017.
  2. "Deafness Research Foundation Announces New Name and Reaffirms its Unwavering Dedication to..." New York: Prnewswire.com. 2011-09-14. Retrieved 2012-07-16.
  3. "Deafness Research Foundation Announces New Name". PRNewswire. 14 September 2011. Retrieved 7 January 2013.
  4. "Hearing Health Foundation History". Hearinghealthfoundation.org. 1958-02-01. Retrieved 2017-08-22.
  5. "Collette Ramsey Baker". TC Palm. 12 May 2010. Retrieved 7 January 2013.
  6. "What is the Registry?". National Temporal Bone Registry. Retrieved 7 January 2013.
  7. Edge AS, Chen ZY (2008). "Hair cell regeneration". Current Opinion in Neurobiology. 18 (4): 377–82. doi:10.1016/j.conb.2008.10.001. PMC 5653255. PMID 18929656.
  8. "Hearing Health Foundation History". Hearinghealthfoundation.org. 1958-02-01. Retrieved 2017-08-22.
  9. "Hearing Restoration Project (HRP) - International Scientific Consortium". Hearing Health Foundation.
  10. "Hearing Health Summit 2011". hyperacusisresearch.org. Retrieved 2017-08-22.
  11. "Safe and Sound Prevention Program". Hearinghealthfoundation.org. Retrieved 2013-10-28.
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