HOMER3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[5][6][7]

HOMER3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P8V, 3CVF
Identifiers
Aliases	HOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDs	OMIM: 604800 MGI: 1347359 HomoloGene: 37972 GeneCards: HOMER3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,929,201 bp[1] End 18,941,261 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,282,827 bp[2] End 70,294,361 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein C-terminus binding • GO:0001948 protein binding • protein domain specific binding • G-protein coupled glutamate receptor binding • identical protein binding Cellular component • basal part of cell • cell junction • postsynaptic membrane • synapse • GO:0097483, GO:0097481 postsynaptic density • membrane • cytoplasm • cytosol • cell membrane • cellular component • glutamatergic synapse • dendrite • neuron projection Biological process • G-protein coupled glutamate receptor signaling pathway • protein targeting • negative regulation of interleukin-2 production • negative regulation of calcineurin-NFAT signaling cascade • regulation of postsynaptic neurotransmitter receptor activity • regulation of store-operated calcium entry Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9454	26558
Ensembl	ENSG00000051128	ENSMUSG00000003573
UniProt	Q9NSC5	Q99JP6
RefSeq (mRNA)	NM_001145721 NM_001145722 NM_001145724 NM_004838	NM_001146153 NM_011984
RefSeq (protein)	NP_001139193 NP_001139194 NP_001139196 NP_004829 NP_001139194.1 NP_001139196.1	NP_001139625 NP_036114
Location (UCSC)	Chr 19: 18.93 – 18.94 Mb	Chr 8: 70.28 – 70.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[7]

Interactions

HOMER3 has been shown to interact with TRPC1[8] and RYR1.[9]

See also

• HOMER1
• HOMER2

References

1. GRCh38: Ensembl release 89: ENSG00000051128 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003573 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
6. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
7. "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
8. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576.
9. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.

Further reading

• Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF (Mar 1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.
• Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Oct 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
• Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
• Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576.
• Ishiguro K, Xavier R (Mar 2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain". Blood. 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
• Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genetics. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
• Schreiner D, Müller K, Hofer HW (Oct 2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Letters. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.