HOMER2

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.[5][6][7]

HOMER2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDsOMIM: 604799 MGI: 1347354 HomoloGene: 3560 GeneCards: HOMER2
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q25.2Start82,836,946 bp[1]
End82,986,153 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9455

26557

Ensembl

ENSG00000103942

ENSMUSG00000025813

UniProt

Q9NSB8

Q9QWW1

RefSeq (mRNA)

NM_004839
NM_199330
NM_199331
NM_199332

NM_001164086
NM_001164087
NM_011983
NM_177029

RefSeq (protein)

NP_004830
NP_955362

NP_001157558
NP_001157559
NP_036113

Location (UCSC)Chr 15: 82.84 – 82.99 MbChr 7: 81.6 – 81.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.[7]

Interactions

HOMER2 has been shown to interact with RYR1.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000103942 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025813 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
  6. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
  7. "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
  8. Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. United States. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Further reading


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