HLA-DR15

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

major histocompatibility complex, class II, DR15
Haplotypes groups DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1501 to *1505 *1507
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1501
EBI-HLA DRB1*1502
EBI-HLA DRB1*1503
EBI-HLA DRB1*1504
EBI-HLA DRB1*1505
EBI-HLA DRB1*1507
Shared data
Locus chr.6 6p21.31

Serology
DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1*DR15 DR2DR16Sample
allele%%%size (N)
150176236428
15027716676
15038113286
1504>501
1505>252
1507>501

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively associated Goodpasture syndrome,[2] early age onset multiple sclerosis,[3] pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7] and a predisposition for postmenopausal osteoporosis.[8]

DRB1*1501 is positively associated with Goodpasture syndrome,[9][10] juvenile rheumatoid arthritis,[11] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] systemic lupus erythematosus,[14] cervical cancer (human papillomavirus infection),[15] Sjögren syndrome associated with systemic lupus erythematosus,[16] and intermediate uveitis.[17]

DRB1*1502 is associated with systemic lupus erythematosus,[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.[19]

DRB1*1503 is associated with Chaga's cardiomyopathy,[20] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] cervical cancer (human papillomavirus infection).[21]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[21]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[18]

Genetic Linkage
DR15 Haplotypes
Serotypes DRADRB1DRB5
DR15(2)-DR51 *0101*1501*0101
*0101*1502*0101
*0101*1503*0101
*0101*1504*0101
*0101*1505*0101
*0101*1507*0101
DQA1DQB1DRB1
DR15(2)-DQ6(6.2, 1) *0102*0602*1501
DR15(2)-DQ6(6.1, 1) *0103*0601*1502
HLA-AHLA-BDRB1
A3-Cw7-B7-DR15(2) *0301*0702*1501
A1-B51-DR15(2) *0101*5101*1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

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References
  1. derived from IMGT/HLA
  2. Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease". Int Immunol. 12 (8): 1135–43. doi:10.1093/intimm/12.8.1135. PMID 10917888.
  3. Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis". Annals of Neurology. 48 (2): 211–9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572.
  4. Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768–70. doi:10.1136/bmj.282.6266.768. PMC 1504598. PMID 6783164.
  5. Bilir M, Sipahi S, Yilmaz E, et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393.
  6. Hong SC, Lin L, Lo B, et al. (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
  7. Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217.
  8. Douroudis K, Tarassi K, Athanassiades T, et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
  9. Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int. 68 (3): 1061–70. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036.
  10. Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int. 56 (5): 1638–53. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772.
  11. Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
  12. Slavin R, Hutcheson P, Chauhan B, Bellone C (2004). "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
  13. Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens. 61 (2): 166–71. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585.
  14. Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". Int J Immunogenet. 32 (3): 173–8. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622.
  15. Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet. 6 (2): 157–62. doi:10.1038/ng0294-157. PMID 8162070.
  16. Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum. 50 (3): 882–91. doi:10.1002/art.20093. PMID 15022331.
  17. Petrushkin, Harry; Thomas, Dhanes; Vaughan, Robert; Kondeatis, Elli; Stanford, Miles R.; Edelsten, Clive; Wallace, Graham R. (2015-04-01). "Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis". JAMA Ophthalmology. 133 (4): 482–483. doi:10.1001/jamaophthalmol.2014.5868. ISSN 2168-6165.
  18. Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 59 (2): 113–7. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537.
  19. Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
  20. García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem. 43 (Pt 3): 214–6. doi:10.1258/000456306776865205. PMID 16704757.
  21. Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev. 9 (11): 1183–91. PMID 11097225.
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