HLA-DOA

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[5][6]

HLA-DOA
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDsOMIM: 142930 MGI: 95924 HomoloGene: 1601 GeneCards: HLA-DOA
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.32Start33,004,182 bp[1]
End33,009,591 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3111

15001

Ensembl

ENSMUSG00000024334

UniProt

P06340

n/a

RefSeq (mRNA)

NM_002119

NM_008206

RefSeq (protein)

NP_002110

n/a

Location (UCSC)Chr 6: 33 – 33.01 MbChr 17: 34.09 – 34.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[6]

References

  1. ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024334 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084.
  6. "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

Further reading

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