HHIP

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.[5][6][7]

HHIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHHIP, HIP, hedgehog interacting protein
External IDsOMIM: 606178 MGI: 1341847 HomoloGene: 32469 GeneCards: HHIP
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q31.21Start144,646,156 bp[1]
End144,745,271 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64399

15245

Ensembl

ENSG00000164161

ENSMUSG00000064325

UniProt

Q96QV1

Q7TN16

RefSeq (mRNA)

NM_022475

NM_020259

RefSeq (protein)

NP_071920

NP_064655

Location (UCSC)Chr 4: 144.65 – 144.75 MbChr 8: 79.97 – 80.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000164161 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000064325 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet. 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703.
  6. Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev. 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473.
  7. "Entrez Gene: HHIP hedgehog interacting protein".

Further reading


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