Gaseous mediator

Gaseous mediators are chemicals that are produced in small amounts by some cells of the mammalian body and have a number of biological signalling functions. There are three so-far-identified gaseous mediator molecules: nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO).[1]

Clinical Applications

Endogenous gaseous mediators have shown anti-inflammatory and cytoprotective properties[2] Combination nonsteroidal anti-inflammatory drugs featuring both a cyclooxygenase inhibitor and gaseous mediator releasing component are being investigated as a safer alternative to current anti-inflammatory drugs[3] due to their potential reduction in risk for gastrointestinal ulcer formation.[4]

gollark: The luck potion thing?
gollark: It's very pro-death and I dislike this.
gollark: <@356107472269869058>
gollark: 1. random mistreated boy turns out to be magic, goes to boarding school, kills professor with fire (insane headmaster explains it as his mother's love)2. boy talks to snakes, kills an endangered species, kills professor again3. boy helps fugitive who escaped from wizard prison, breaks out dangerous animal, meddles with the laws of time itself4. boy is entered in ridiculously dangered banned tournament allegedly against his will, unwillingly resurrects professor5. boy participates in secret rebel group or whatever, I forgot6. ???, potions, ???, unethically manipulates professor via probability fiddling maybe7. boy becomes fugitive, re-kills professor, dies, un-dies, etc.
gollark: The summarizing or the reading it?

References
  1. Leffler, C. W.; Parfenova, H; Jaggar, J. H.; Wang, R (March 2006). "Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation". J. Appl. Physiol. 100 (3): 1065–76. doi:10.1152/japplphysiol.00793.2005. PMC 1363746. PMID 16467393.
  2. Rodrigues, L.; Ekundi-Valentim, E.; Florenzano, J.; Cerqueira, A. R. A.; Soares, A. G.; Schmidt, T. P.; Santos, K. T.; Teixeira, S. A.; Ribela, M. T. C. P.; Rodrigues, S. F.; de Carvalho, M. H. (2017-01-01). "Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice". Pharmacological Research. 115: 255–266. doi:10.1016/j.phrs.2016.11.006. hdl:10871/24576. ISSN 1043-6618.
  3. Sulaieva, Oksana; Wallace, John L (2015-12-01). "Gaseous mediator-based anti-inflammatory drugs". Current Opinion in Pharmacology. Gastrointestinal • Endocrine and metabolic diseases. 25: 1–6. doi:10.1016/j.coph.2015.08.005. ISSN 1471-4892.
  4. Sulaieva, O. N.; Wallace, J. L. (2016). "New strategy for gastrointestinal protection based on gaseous mediators application". Russian Journal of Gastroenterology, Hepatology, Coloproctology. Retrieved 2020-04-27.


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