Gard model

In evolutionary biology, the GARD (Graded Autocatalysis Replication Domain) model is a general kinetic model for homeostatic-growth and fission of compositional-assemblies, with specific application towards lipids.[1]

In the context of abiogenesis, the lipid-world[2] suggests assemblies of simple molecules, such as lipids, can store and propagate information, thus undergo evolution.

These 'compositional assemblies' have been suggested to play a role in the origin of life. The idea is the information being transferred throughout the generations is compositional information – the different types and quantities of molecules within an assembly. This is different from the information encoded in RNA or DNA, which is the specific sequence of bases in such molecule. Thus, the model is viewed as an alternative or an ancestor to the RNA world hypothesis.

The model

The composition vector of an assembly is written as: . Where are the molecular counts of lipid type i within the assembly, and NG is how many different lipid types exist (repertiore size).

The change in the count of molecule type i is described by:

and are the basel forward (joining) and backward (leaving) rate constants, βij is a non-negative rate enhancement exerted by molecule type j within the assembly on type i from the environment, and ρ is the environmental concentration of each molecule type. β is viewed as a directed, weighted, complex network.

The assembly current size is . The system is kept away from equilibrium by imposing a fission action once the assembly reaches a maximal size, Nmax, usually in the order of NG. This splitting action produces two progeny of same size, and one of which is grown again.

The model is subjected to a Monte Carlo algorithm based simulations, using Gillespie algorithm.

Selection

In 2010, Eors Szathmary and collaborators have chosen GARD as an archetypal metabolism-first realization.[3] They have introduced selection coefficient into the model, which increase or decrease the growth rate of assemblies, depending on how similar or dis-similar they are to a given target. They found that the ranking of the assemblies are un-affected by the selection pressure, and concluded that GARD does not exhibit Darwinian evolution.

In 2012 it was shown that this criticism is erroneous and was refuted.[4] Two major drawbacks of the 2010 paper were: (1) they have focused on a general assembly and not on a composome or compotype (faithfully replicating and quasispecies, respectively); (2) they have performed only a single, random, simulation to test the selectability.

Quasispecies

The quasispecies model describes a population of replicators that replicate with relatively high mutations. Due to mutations and back mutations the population eventually centres around a master-replicator (master sequence). GARD's populations were shown to form a quasispecies around a master-compotype and to exhibit an Error catastrophe, similarly to classical quasispecis such as RNA viruses.[5]

gollark: Or use a relay?
gollark: Or a linked card.
gollark: Also, you can just use a wireless card?
gollark: I'd rather be ultra-fancy and have it access some push notification API and send a notification to my phone.
gollark: IRC? What does that have to do with anything?

See also

References
  1. Segré, Daniel; Ben-Eli, Dafna; Lancet, Doron (11 April 2000). "Compositional genomes: Prebiotic information transfer in mutually catalytic noncovalent assemblies". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 4112–4117. Bibcode:2000PNAS...97.4112S. doi:10.1073/pnas.97.8.4112. PMC 18166. PMID 10760281.
  2. Segre, D.; Ben-Eli, D.; Deamer, D.; Lancet, D. (2001). "The lipid world". Orig Life Evol Biosph. 31 (1–2): 119–145. Bibcode:2001OLEB...31..119S. doi:10.1023/A:1006746807104. PMID 11296516. S2CID 10959497.
  3. Vasas, Vera; Szathmáry, Eörs; Santos, Mauro (26 January 2010). "Lack of evolvability in self-sustaining autocatalytic networks constraints metabolism-first scenarios for the origin of life". Proceedings of the National Academy of Sciences of the United States of America. 107 (4): 1470–1475. Bibcode:2010PNAS..107.1470V. doi:10.1073/pnas.0912628107. PMC 2824406. PMID 20080693.
  4. Markovitch, O.; Lancet, D. (2012). "Excess Mutual Catalysis Is Required for Effective Evolvability". Artificial Life. 18 (3): 243–266. doi:10.1162/artl_a_00064. PMID 22662913. S2CID 5236043.
  5. Gross, Renan; Fouxon, Itzhak; Lancet, Doron; Markovitch, Omer (30 December 2014). "Quasispecies in population of compositional assemblies". BMC Evolutionary Biology. 14 (1): 265. doi:10.1186/s12862-014-0265-1. PMC 4357159. PMID 25547629.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.