GPVI

Glycoprotein VI (platelet), also known as GPVI, is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.[5] GPVI was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.

GP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GI7
Identifiers
Aliases	GP6, BDPLT11, GPIV, GPVI, glycoprotein VI platelet
External IDs	OMIM: 605546 MGI: 1889810 HomoloGene: 9488 GeneCards: GP6
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,013,705 bp[1] End 55,038,264 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,363,965 bp[2] End 4,397,744 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transmembrane signaling receptor activity • receptor activity • collagen binding • signaling receptor activity Cellular component • integral component of membrane • cell surface • cell membrane • tetraspanin-enriched microdomain • extracellular exosome • membrane • integral component of plasma membrane Biological process • platelet activation • hemostasis • blood coagulation • enzyme linked receptor protein signaling pathway • leukocyte migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51206	243816
Ensembl	ENSG00000088053 ENSG00000274050 ENSG00000278670 ENSG00000276211 ENSG00000277439 ENSG00000278316 ENSG00000275633 ENSG00000274566 ENSG00000275931 ENSG00000276065	ENSMUSG00000078810
UniProt	Q9HCN6	P0C191
RefSeq (mRNA)	NM_016363 NM_001083899 NM_001256017	NM_001163014
RefSeq (protein)	NP_001077368 NP_001242946 NP_057447	NP_001156486
Location (UCSC)	Chr 19: 55.01 – 55.04 Mb	Chr 7: 4.36 – 4.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.[6][7]

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions

GPVI has been shown to interact with LYN.[8]

See also

• collagen receptor

References

1. ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633, ENSG00000274566, ENSG00000275931, ENSG00000276065 GRCh38: Ensembl release 89: ENSG00000088053, ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633, ENSG00000274566, ENSG00000275931, ENSG00000276065 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078810 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
6. "Entrez Gene: GP6 glycoprotein VI (platelet)".
7. Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (Sep 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood. 96 (5): 1798–807. doi:10.1182/blood.V96.5.1798. PMID 10961879.
8. Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". The Journal of Biological Chemistry. 277 (24): 21561–6. doi:10.1074/jbc.M201012200. PMID 11943772.

Further reading

• Nieswandt B, Watson SP (Jul 2003). "Platelet-collagen interaction: is GPVI the central receptor?". Blood. 102 (2): 449–61. doi:10.1182/blood-2002-12-3882. PMID 12649139.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (Aug 2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". Journal of Thrombosis and Haemostasis. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
• Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (Sep 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proceedings of the National Academy of Sciences of the United States of America. 88 (17): 7844–8. Bibcode:1991PNAS...88.7844H. doi:10.1073/pnas.88.17.7844. PMC 52400. PMID 1715582.
• Moroi M, Jung SM, Okuma M, Shinmyozu K (Nov 1989). "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion". The Journal of Clinical Investigation. 84 (5): 1440–5. doi:10.1172/JCI114318. PMC 304007. PMID 2808700.
• Polgár J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ (May 1997). "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". The Journal of Biological Chemistry. 272 (21): 13576–83. doi:10.1074/jbc.272.21.13576. PMID 9153205.
• Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP (Aug 1997). "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain". FEBS Letters. 413 (2): 255–9. doi:10.1016/S0014-5793(97)00926-5. PMID 9280292.
• Tsuji M, Ezumi Y, Arai M, Takayama H (Sep 1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry. 272 (38): 23528–31. doi:10.1074/jbc.272.38.23528. PMID 9295288.
• Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ (Oct 1999). "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors". The Journal of Biological Chemistry. 274 (41): 29019–24. doi:10.1074/jbc.274.41.29019. PMID 10506151.
• Miura Y, Ohnuma M, Jung SM, Moroi M (May 2000). "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI". Thrombosis Research. 98 (4): 301–9. doi:10.1016/S0049-3848(00)00182-1. PMID 10822077.
• Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H (Aug 2000). "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain". The Journal of Biological Chemistry. 275 (31): 23998–4002. doi:10.1074/jbc.M003803200. PMID 10825177.
• Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (Sep 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood. 96 (5): 1798–807. doi:10.1182/blood.V96.5.1798. PMID 10961879.
• Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochemical and Biophysical Research Communications. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
• Barry FA, Gibbins JM (Apr 2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The Journal of Biological Chemistry. 277 (15): 12874–8. doi:10.1074/jbc.M200482200. PMID 11825911.
• Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". The Journal of Biological Chemistry. 277 (24): 21561–6. doi:10.1074/jbc.M201012200. PMID 11943772.
• Quinton TM, Ozdener F, Dangelmaier C, Daniel JL, Kunapuli SP (May 2002). "Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP". Blood. 99 (9): 3228–34. doi:10.1182/blood.V99.9.3228. PMID 11964287.
• Saving KL, Mankin PE, Gorman MJ (Feb 2002). "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults". Journal of Pediatric Hematology/Oncology. 24 (2): 120–4. doi:10.1097/00043426-200202000-00012. PMID 11990697.
• Andrews RK, Suzuki-Inoue K, Shen Y, Tulasne D, Watson SP, Berndt MC (Jun 2002). "Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI" (PDF). Blood. 99 (11): 4219–21. doi:10.1182/blood-2001-11-0008. PMID 12010829.
• Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP (Jun 2002). "Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets". The Biochemical Journal. 364 (Pt 3): 755–65. doi:10.1042/BJ20020128. PMC 1222625. PMID 12049640.
• Miura Y, Takahashi T, Jung SM, Moroi M (Nov 2002). "Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen". The Journal of Biological Chemistry. 277 (48): 46197–204. doi:10.1074/jbc.M204029200. PMID 12356768.
• Holmes ML, Bartle N, Eisbacher M, Chong BH (Dec 2002). "Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1". The Journal of Biological Chemistry. 277 (50): 48333–41. doi:10.1074/jbc.M206127200. PMID 12359731.

External links

• GPVI+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)