Françoise Gisou van der Goot

Françoise Gisou van der Goot (born in 1964 in Tehran)[1] is a Dutch cell biologist. She is a professor at the École Polytechnique Fédérale de Lausanne (EPFL) and the dean of the Faculty of Lifes Sciences at EPFL.

Professor

Françoise Gisou Van der Goot
Gisou van der Goot in 2018
Born
Tehran, Iran
Spouse(s)Jean Gruenberg
AwardsEMBO Young Investigator Award (2001)
Howard Hughes Internation Scholar award (2005)
Leenaards Foundation Research Prize (2009)
Marcel Benoist Prize (2009)
Academic background
Alma materÉcole Centrale de Paris
Academic work
DisciplineCell biology
InstitutionsÉcole Polytechnique Fédérale de Lausanne (EPFL)
Main interestsMembrane transport, Anthrax toxin, Juvenile hyaline fibromatosis
Websitehttps://www.epfl.ch/labs/vdg/

Career

Van der Goot studied engineering at the École Centrale de Paris. She pursued a PhD in molecular biophysics at the Saclay Nuclear Research Centre (Pierre and Marie Curie University), and then a postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg. In 1994 she worked as a group leader in the Department of Biochemistry of the University of Geneva and, subsequently, from 2001 as associate professor in the department of microbiology and molecular medicine. Since 2006 she has been full professor of molecular and cellular microbiology at the Faculty of Life Sciences of the École polytechnique fédérale de Lausanne.[2][3] Currently she is dean of the School of Life Sciences at École polytechnique fédérale de Lausanne[4].

Research

Van der Goot leads the Laboratory of Cell and Membrane Biology at the School of Life Sciences of the École Polytechnique Fédérale de Lausanne (EPFL)[5]. Her laboratory studies various aspects of cellular and intracellular membrane dynamics. Notably, it aims to better understand the way protein palmitoylation regulates endoplasmic reticulum function and protein trafficking[6], the mechanisms which allow bacterial proteins such as the anthrax toxin to penetrate target cells[7], and the molecular mechanisms leading to juvenile hyaline fibromatosis, a rare and debilitating genetic disorder[8]. In the context of the COVID-19 pandemic, van der Goot declared to have dedicated part of her laboratory to study SARS-CoV-2[9].

Distinctions

Van der Goot obtained an EMBO Young Investigator award[10] in 2001 and an Howard Hughes International Scholar award in 2005. In 2009, van der Goot received the Leenaards Foundation Research Prize[11] and the Marcel Benoist Prize.[12] The latter two prizes were awarded for her contributions to the biochemistry of the bacterial toxin of the anthrax pathogen at the host cell membrane.

Van der Goot has been member of scientific boards such as the Swiss National Science Foundation,[13] the Swiss Science Council and the European Research Council (ERC).[2]

Personal life

Van der Goot is married to Swiss biologist Jean Gruenberg and has two children.

References
  1. "Françoise Gisou van der Goot reçoit le Prix Marcel Benoist 2009". www.admin.ch. Retrieved 2020-08-01.
  2. "Gisou van der Goot". people.epfl.ch. Retrieved 2020-07-29.
  3. "Van der Goot Lab ‐ EPFL". Retrieved 2020-07-29.
  4. Evangelista, Sandy (2020-04-06). ""The most important thing is staying in touch"". Cite journal requires |journal= (help)
  5. "van der Goot Lab – Laboratory of Cell and Membrane Biology". www.epfl.ch. Retrieved 2020-08-13.
  6. Blaskovic, Sanja; Blanc, Mathieu; Goot, F. Gisou van der (2013). "What does S-palmitoylation do to membrane proteins?". The FEBS Journal. 280 (12): 2766–2774. doi:10.1111/febs.12263. ISSN 1742-4658.
  7. Abrami, Laurence; Liu, Shihui; Cosson, Pierre; Leppla, Stephen H.; van der Goot, F. Gisou (2003-02-03). "Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process". Journal of Cell Biology. 160 (3): 321–328. doi:10.1083/jcb.200211018. ISSN 0021-9525.
  8. Deuquet, Julie; Lausch, Ekkehart; Guex, Nicolas; Abrami, Laurence; Salvi, Suzanne; Lakkaraju, Asvin; Ramirez, Maria Celeste M.; Martignetti, John A.; Rokicki, Dariusz; Bonafe, Luisa; Superti-Furga, Andrea (2011-04-01). "Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors". EMBO Molecular Medicine. 3 (4): 208–221. doi:10.1002/emmm.201100124. ISSN 1757-4676. PMC 3377065. PMID 21328543.
  9. "Gisou van der Goot, de l'anthrax au Covid-19". Le Temps (in French). 2020-07-02. ISSN 1423-3967. Retrieved 2020-08-13.
  10. "Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 2020-07-29.
  11. "Etude des mécanismes amenant des pathogènes à être mortels pour l'homme". Fondation Leenaards - Favoriser la dynamique créatrice (in French). Retrieved 2020-07-29.
  12. "Past laureates – Marcel Benoist Foundation". marcel-benoist.ch. Retrieved 2020-08-01.
  13. "Former SSC members". www.swir.ch. Retrieved 2020-07-29.
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