FOXI3

Forkead box I3 (FOXI3) is a protein that in humans is encoded by the FOXI3 gene. FOXI3 is a forkhead box transcription factor that is expressed in the development of hair and teeth. One of its mutations is a dominant allele responsible for the heterozygous Hh hairless trait in dogs. It was identified in 2008.[4]

FOXI3
Identifiers
Aliases	FOXI3, forkhead box I3
External IDs	OMIM: 612351 MGI: 3511278 HomoloGene: 52949 GeneCards: FOXI3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 88,446,787 bp[1] End 88,452,693 bp[1]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	344167	232077
Ensembl	ENSG00000214336	n/a
UniProt	A8MTJ6	n/a
RefSeq (mRNA)	NM_001135649	NM_001101464
RefSeq (protein)	NP_001129121	n/a
Location (UCSC)	Chr 2: 88.45 – 88.45 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Chinese Crested Dog
• Mexican Hairless Dog
• Peruvian Inca Orchid (Peruvian Hairless Dog)
• Dog coat genetics

References

1. GRCh38: Ensembl release 89: ENSG00000214336 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science. 321 (5895): 1462. doi:10.1126/science.1162525. PMID 18787161.