FLOT1

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[5]

FLOT1
Identifiers
Aliases	FLOT1, flotillin 1
External IDs	OMIM: 606998 MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,727,709 bp[1] End 30,742,732 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,823,230 bp[2] End 35,832,791 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protease binding • GO:0001948 protein binding • protein heterodimerization activity • ionotropic glutamate receptor binding Cellular component • integral component of membrane • endosome • membrane • cell-cell contact zone • focal adhesion • plasma membrane raft • melanosome • cell membrane • centriolar satellite • microtubule organizing center • lysosomal membrane • flotillin complex • uropod • basolateral plasma membrane • early endosome • apical plasma membrane • cortical actin cytoskeleton • caveola • membrane raft • COP9 signalosome • sarcolemma • extracellular exosome • cytoplasmic vesicle • lamellipodium • intercellular junction • external side of plasma membrane • synapse • presynaptic active zone • dopaminergic synapse • presynapse • glutamatergic synapse • GABA-ergic synapse Biological process • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of cell adhesion molecule production • positive regulation of protein phosphorylation • regulation of toll-like receptor 4 signaling pathway • positive regulation of heterotypic cell-cell adhesion • positive regulation of toll-like receptor 3 signaling pathway • axonogenesis • positive regulation of skeletal muscle tissue development • positive regulation of cytokine production • extracellular matrix disassembly • protein kinase C signaling • response to endoplasmic reticulum stress • positive regulation of myoblast fusion • positive regulation of endocytosis • positive regulation of cell junction assembly • protein localization to membrane raft • membrane raft assembly • cellular response to exogenous dsRNA • regulation of receptor internalization • positive regulation of synaptic transmission, dopaminergic • positive regulation of protein binding • regulation of Rho protein signal transduction • protein homooligomerization • dsRNA transport • plasma membrane raft assembly • positive regulation of interferon-beta production • protein stabilization • protein localization to plasma membrane • regulation of neurotransmitter uptake • positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10211	14251
Ensembl	ENSG00000137312 ENSG00000232280 ENSG00000224740 ENSG00000206480 ENSG00000206379 ENSG00000230143 ENSG00000236271 ENSG00000223654	ENSMUSG00000059714
UniProt	O75955	O08917
RefSeq (mRNA)	NM_005803 NM_001318875	NM_008027
RefSeq (protein)	NP_001305804 NP_005794	NP_032053
Location (UCSC)	Chr 6: 30.73 – 30.74 Mb	Chr 17: 35.82 – 35.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[6] The function of flotillin 1 has not been determined.[5]

Interactions

FLOT1 has been shown to interact with SORBS1.[7][8][9]

References

1. ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059714 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FLOT1 flotillin 1".
6. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
7. Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
8. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060.
9. Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe". J. Biol. Chem. 274 (18): 12702–9. doi:10.1074/jbc.274.18.12702. PMID 10212252.
• Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation". J. Cell. Biochem. 75 (1): 147–59. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D. PMID 10462713.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts". Blood. 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID 11159550.
• Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals". Int. J. Biochem. Cell Biol. 33 (1): 53–64. doi:10.1016/S1357-2725(00)00069-8. PMID 11167132.
• Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.
• Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2". Mol. Biol. Cell. 12 (10): 3031–45. doi:10.1091/mbc.12.10.3031. PMC 60153. PMID 11598189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. doi:10.1051/jbio/2003197030223. PMID 14708344.
• Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID 15120622.
• Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
• Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Mol. Biol. Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain". Neurotoxicity Research. 6 (4): 245–57. doi:10.1007/BF03033435. PMID 15545008.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
• Glebov OO, Bright NA, Nichols BJ (2006). "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells". Nat. Cell Biol. 8 (1): 46–54. doi:10.1038/ncb1342. PMID 16341206.

External links

• FLOT1 human gene location in the UCSC Genome Browser.
• FLOT1 human gene details in the UCSC Genome Browser.