FCRL4

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.[3][4][5]

FCRL4
Identifiers
Aliases	FCRL4, CD307d, FCRH4, IGFP2, IRTA1, Fc receptor like 4
External IDs	OMIM: 605876 HomoloGene: 88926 GeneCards: FCRL4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 157,573,747 bp[1] End 157,598,085 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • membrane • cell surface Biological process • adaptive immune response • immune system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83417	n/a
Ensembl	ENSG00000163518	n/a
UniProt	Q96PJ5	n/a
RefSeq (mRNA)	NM_031282	n/a
RefSeq (protein)	NP_112572	n/a
Location (UCSC)	Chr 1: 157.57 – 157.6 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000163518 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity. 14 (3): 277–89. doi:10.1016/S1074-7613(01)00109-1. PMID 11290337.
4. Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
5. "Entrez Gene: FCRL4 Fc receptor-like 4".

Further reading

• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
• Ehrhardt GR, Hsu JT, Gartland L, et al. (2005). "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells". J. Exp. Med. 202 (6): 783–91. doi:10.1084/jem.20050879. PMC 2212938. PMID 16157685.
• Jöhrens K, Shimizu Y, Anagnostopoulos I, et al. (2006). "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution". Haematologica. 90 (8): 1070–7. PMID 16079106.
• Falini B, Tiacci E, Pucciarini A, et al. (2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)". Blood. 102 (10): 3684–92. doi:10.1182/blood-2003-03-0750. PMID 12881317.
• Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics. 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601.
• Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.