FCHSD2

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.[5][6][7]

FCHSD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DL5, 2DL7
Identifiers
Aliases	FCHSD2, NWK, SH3MD3, FCH and double SH3 domains 2, NWK1
External IDs	OMIM: 617556 MGI: 2448475 HomoloGene: 8887 GeneCards: FCHSD2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,836,745 bp[1] End 73,142,318 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,092,863 bp[2] End 101,284,405 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • lipid binding Cellular component • neuromuscular junction • recycling endosome • cell membrane • clathrin-coated pit • stereocilium shaft • cytoplasm • membrane • cell junction • stereocilium • cell projection Biological process • neuromuscular synaptic transmission • regulation of actin filament polymerization • positive regulation of actin filament polymerization • multi-organism membrane organization • clathrin-dependent endocytosis • positive regulation of Arp2/3 complex-mediated actin nucleation • endocytosis • protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9873	207278
Ensembl	ENSG00000137478	ENSMUSG00000030691
UniProt	O94868	Q3USJ8
RefSeq (mRNA)	NM_014824	NM_001146010 NM_199012
RefSeq (protein)	NP_055639	NP_001139482 NP_950177
Location (UCSC)	Chr 11: 72.84 – 73.14 Mb	Chr 7: 101.09 – 101.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

FCHSD2 has been shown to interact with MAGI1[8] and C2orf73.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000137478 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030691 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. Katoh M, Katoh M (May 2004). "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico". International Journal of Molecular Medicine. 13 (5): 749–54. doi:10.3892/ijmm.13.5.749. PMID 15067381.
7. "Entrez Gene: FCHSD2 FCH and double SH3 domains 2".
8. Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.
9. Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ (August 2008). "Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach". Proteomics. 8 (15): 3071–81. doi:10.1002/pmic.200701157. PMID 18654987.

Further reading

• Petitjean C, Scheydeker JL, Suinat JL, Rendoing J (1976). "[Pulmonary edema in hangings]". De l'Anesthésiologie Française. 16. 16 Spec No 2-3: 57–65. PMID 9873.
• Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.
• Coyle IP, Koh YH, Lee WC, Slind J, Fergestad T, Littleton JT, Ganetzky B (February 2004). "Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila". Neuron. 41 (4): 521–34. doi:10.1016/S0896-6273(04)00016-9. PMID 14980202.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (March 2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.