Eva Feldman

Eva Lucille Feldman, M.D., Ph.D., F.A.A.N., F.A.N.A.[1] is an American physician and the Russell N. DeJong Professor of Neurology at the University of Michigan. She is the Director of the NeuroNetwork for Emerging Therapies and Director of the University of Michigan ALS Center of Excellence, which includes the Pranger ALS Clinic. She is annually listed in Best Doctors in America,[2] is a Past President of the Peripheral Nerve Society and the American Neurological Association, and a member of the National Academy of Medicine and Association of American Physicians.[1]

For American child actress, see Eva Lee Kuney.

Early life and education

Having grown up in Indiana, Feldman completed her B.A. in biology at Earlham College and was introduced to medical research early in her college career. She earned an M.S. in zoology from the University of Notre Dame, then received her Ph.D. (1979) and M.D. (1983) in neuroscience at the University of Michigan Medical School in the laboratory of Dr. Bernard Agranoff. She performed her residency in neurology (1988) at The Johns Hopkins Hospital where she served as chief resident and the first neurologist to receive The Johns Hopkins Award for Medical Teaching and Excellence. She returned to the University of Michigan to complete a fellowship in neuromuscular disease (1988) and has remained on faculty ever since.[3]

  • B.A. - Biology, Earlham College (1973)
  • M.S. - Zoology, University of Notre Dame (1975)
  • Ph.D. - Neuroscience, University of Michigan (1979)
  • M.D. - Neuroscience, University of Michigan (1983)
  • Resident - Neurology, The Johns Hopkins Hospital (1987)
  • Fellow - Neuromuscular Disease, University of Michigan (1988)

Career

Feldman has made contributions to medical research and clinical care in many critical areas, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease and complications in diabetes. She developed a clinical screening instrument for the rapid diagnosis of diabetic neuropathy,[4] which is currently being used worldwide. She conducted the first human clinical trial of a stem cell therapy for ALS.[5]

She has successfully developed and translated a stem cell therapy for ALS from bench to bedside, conducting the first Phase 1 and 2 FDA approved human trials evaluating intraspinal transplantation of spinal cord stem cells 19,21,39.[6][7][8]

In January 2008, Feldman was named the first director of the A. Alfred Taubman Medical Research Institute, which was created to support fundamental research into a wide range of human diseases. Under her leadership, the Taubman Institute funds senior-level scientists in a diverse spectrum of diseases: adult and childhood cancer, ALS, diabetes, cardiovascular disease and hearing loss. She remained director until 2017.[9]

In the fall of 2008, Feldman and the Taubman Institute played a role in educating Michigan citizens on the importance of stem cell research in the study and treatment of disease. In the November election, voters approved a constitutional amendment lifting restrictions on stem cell research in the state. As a result of the election, the Taubman Institute opened the first core facilities in the Michigan dedicated to the derivation of embryonic stem cell lines and one of the few in the nation. In her own work, Feldman is considered a pioneer in the application of stem cell technology to human disease, most notably the ongoing ALS clinical trial, in which stem cells are implanted in the spinal cords of patients with the disease.[6][7][8] She has also begun the work of adapting this treatment to patients with Alzheimer's disease,[10][11] having received National Institute on Aging funding to support these efforts.[12]

In addition to running an active clinical practice at the University of Michigan, Feldman is the director of the NeuroNetwork for Emerging Therapies, a team of more than 30 scientists who collaborate on the study of a wide variety of neurological diseases, including ALS, diabetic neuropathy, and Alzheimer’s disease. She is also the research director of the U-M Pranger ALS Clinic.

Feldman is the author of more than 460 articles, 71 book chapters and four books. She is the principal investigator or co-PI of 12 major National Institutes of Health research grants, one CDC/ATSDR-funded project, one private foundation grant and multiple clinical trials focused on understanding and treating neurological disorders, with an emphasis on ALS, Alzheimer's disease and diabetic neuropathy. She is Past President of the American Neurological Association and Past President of the Peripheral Nerve Society. Other contributions include, among others, serving on the Strategic Planning Committee for the National Academy of Medicine, and on boards and committees for the Association of American Physicians, American Neurological Association, Juvenile Diabetes Research Foundation, National Institutes of Health, Peripheral Nerve Society Diabetic Neuropathy Consortium, and Diabetic Complications Consortium.

She serves on numerous editorial boards and she is the Neurology Consultant to the Epidemiology of Diabetes Intervention and Complications Trial (EDIC) for the National Institutes of Health (NIH).[13]

Feldman has received many honors, including induction in the National Academy of Medicine, and has earned the Early Career Distinguished Achievement Award, Distinguished Faculty Achievement Award and Distinguished Achievement Award from the University of Michigan. She has also received several scientific achievement awards in the field of diabetes and election to the Johns Hopkins Society of Scholars.[13] Additionally, she has been listed in Best Doctors in America for more than 20 consecutive years. In 2016, Feldman was named a National Physician of the Year by Castle Connolly Medical Ltd.; she was one of three recipients of the Clinical Excellence Award.[2]

Among Dr. Feldman’s greatest accomplishments is her training of both scientists and neurologists. Nine scientists have received their Ph.D. degrees under her, she has trained more than 100 postdoctoral fellows and neurologists to specialize in the understanding and treatment of neuromuscular diseases, with an emphasis on ALS.[13]

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Sources
  • A. Alfred Taubman Medical Research Institute
  • The University of Michigan Health System
  • The American Neurological Association
  • "Stem cell treatment goes from lab to operating room". CNN. May 4, 2010.
  • "UM researcher to test stem cell treatment for Alzheimer's". Crain's Detroit Business. May 2, 2010.
  • "Celling Out". D Business. March–April 2010.
  • "First U.S. stem cells transplanted into spinal cord". CNN. January 21, 2010.

References
  1. "Eva Lucille Feldman MD | Michigan Medicine". www.uofmhealth.org. Retrieved 2018-09-12.
  2. "National Physician of the Year Award Winner". www.castleconnollyawards.com. Retrieved 2018-08-09.
  3. "Eva Lucille Feldman MD | Michigan Medicine". www.uofmhealth.org. Retrieved 2018-08-09.
  4. Herman, W. H.; Pop-Busui, R.; Braffett, B. H.; Martin, C. L.; Cleary, P. A.; Albers, J. W.; Feldman, E. L. (July 2012). "Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications". Diabetic Medicine : A Journal of the British Diabetic Association. 29 (7): 937–944. doi:10.1111/j.1464-5491.2012.03644.x. ISSN 0742-3071. PMC 3641573. PMID 22417277.
  5. Glass, Jonathan D.; Boulis, Nicholas M.; Johe, Karl; Rutkove, Seward B.; Federici, Thais; Polak, Meraida; Kelly, Crystal; Feldman, Eva L. (June 2012). "Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients". Stem Cells. 30 (6): 1144–1151. doi:10.1002/stem.1079. ISSN 1549-4918. PMID 22415942.
  6. Feldman, Eva L.; Boulis, Nicholas M.; Hur, Junguk; Johe, Karl; Rutkove, Seward B.; Federici, Thais; Polak, Meraida; Bordeau, Jane; Sakowski, Stacey A. (March 2014). "Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes". Annals of Neurology. 75 (3): 363–373. doi:10.1002/ana.24113. ISSN 1531-8249. PMC 4005820. PMID 24510776.
  7. Glass, Jonathan D.; Hertzberg, Vicki S.; Boulis, Nicholas M.; Riley, Jonathan; Federici, Thais; Polak, Meraida; Bordeau, Jane; Fournier, Christina; Johe, Karl (2016-07-26). "Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials". Neurology. 87 (4): 392–400. doi:10.1212/WNL.0000000000002889. ISSN 1526-632X. PMC 4977116. PMID 27358335.
  8. Goutman, Stephen A.; Brown, Morton B.; Glass, Jonathan D.; Boulis, Nicholas M.; Johe, Karl; Hazel, Tom; Cudkowicz, Merit; Atassi, Nazem; Borges, Lawrence (June 2018). "Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS". Annals of Clinical and Translational Neurology. 5 (6): 730–740. doi:10.1002/acn3.567. ISSN 2328-9503. PMC 5989736. PMID 29928656.
  9. "Charles Burant appointed as Taubman Institute director". A. Alfred Taubman Medical Research Institute. Retrieved 2018-09-12.
  10. McGinley, Lisa M.; Kashlan, Osama N.; Chen, Kevin S.; Bruno, Elizabeth S.; Hayes, John M.; Backus, Carey; Feldman, Seth; Kashlan, Bader N.; Johe, Karl (October 2017). "Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice". Annals of Clinical and Translational Neurology. 4 (10): 749–755. doi:10.1002/acn3.443. ISSN 2328-9503. PMC 5634341. PMID 29046883.
  11. McGinley, Lisa M.; Sims, Erika; Lunn, J. Simon; Kashlan, Osama N.; Chen, Kevin S.; Bruno, Elizabeth S.; Pacut, Crystal M.; Hazel, Tom; Johe, Karl (March 2016). "Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease". Stem Cells Translational Medicine. 5 (3): 379–391. doi:10.5966/sctm.2015-0103. ISSN 2157-6564. PMC 4807660. PMID 26744412.
  12. "Handleman Emerging Scholar Established to Support Alzheimer's Disease Research". Program for Neurology Research and Discovery. 2018-09-12. Retrieved 2018-09-12.
  13. Eva L. Feldman, M.D., Ph.D., F.A.A.N., CV 8.1.2018. https://www.pnrdfeldman.org/about-us/faculty-staff/

See also
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