Ethylenediamine dihydroiodide

Ethylenediamine dihydroiodide
Names
	IUPAC name Ethane-1,2-diamine dihydroiodide
	Other names Ethylenediammonium diiodide; Jodethamine; Hydrodine
Identifiers
CAS Number	5700-49-2 ;
3D model (JSmol)	Interactive image; Interactive image;
Abbreviations	EDDI
ChemSpider	20604 ;
ECHA InfoCard	100.024.715
PubChem CID	21921;
UNII	721M52NQ5L ;
CompTox Dashboard (EPA)	DTXSID5044570 ;
	InChI InChI=1S/C2H8N2.2HI/c3-1-2-4;;/h1-4H2;21H Key: IWNWLPUNKAYUAW-UHFFFAOYSA-N ; InChI=1/C2H8N2.2HI/c3-1-2-4;;/h1-4H2;21H Key: IWNWLPUNKAYUAW-UHFFFAOYAJ;
	SMILES NCCN.I.I; I.I.NCCN;
Properties
Chemical formula	C2H10I2N2
Molar mass	315.92 g/mol
Appearance	Colorless to light yellow crystalline powder
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Ethylenediamine dihydriodide (EDDI) is a water-soluble salt derived from ethylenediamine and hydroiodic acid. It is a colorless to light yellow crystalline powder. The salt consists of the ethylenediammonium dication C₂H₄(NH₃)₂²⁺ and iodide anions.

Application

EDDI is used as an additive in pet food and cattle feed with high bioavailability. Used to prevent iodine deficiency, this salt is one of the major uses of the element iodine.[1] The United States Food and Drug Administration suggests a limit of intake to 50 mg/head/day.[2] Although EDDI is generally recognized as safe (GRAS) only as a nutrient source of iodine, administration of EDDI also has preventative effects on foot rot in cattle.[3]

Other iodine supplements for animal feed include calcium iodate (most stable) and potassium iodide.

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References

Lyday, Phyllis A. "Iodine and Iodine Compounds" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH, Weinheim, ISBN 978-3-527-30673-2 doi:10.1002/14356007.a14_381 Vol. A14 pp. 382–390.
The Elimination of Iodine Deficiency Disorders, A Resource Package for Central and Eastern Europe, the Commonwealth of Independent States and Baltic States
Berg JN, Maas JP, Paterson JA, Krause GF, Davis LE (1984). "Efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot". Am. J. Vet. Res. 45 (6): 1073–8. PMID 6146277.

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[Ullmann-1] Lyday, Phyllis A. "Iodine and Iodine Compounds" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH, Weinheim, ISBN 978-3-527-30673-2 doi:10.1002/14356007.a14_381 Vol. A14 pp. 382–390.

[2] The Elimination of Iodine Deficiency Disorders, A Resource Package for Central and Eastern Europe, the Commonwealth of Independent States and Baltic States

[3] Berg JN, Maas JP, Paterson JA, Krause GF, Davis LE (1984). "Efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot". Am. J. Vet. Res. 45 (6): 1073–8. PMID 6146277.