Epstein–Barr virus small nucleolar RNA 1
V-snoRNA1 is a box CD-snoRNA identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)).[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.[2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58. It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR of viral DNA polymerase mRNA.[1]
| Human herpesvirus 1 small nucleolar RNA | |
|---|---|
 Sequence concservation of v-snoRNA1 | |
| Identifiers | |
| Symbol | v-snoRNA1 |
| Rfam | RF01516 |
| Other data | |
| RNA type | snoRNA |
| PDB structures | PDBe |
See also
- Epstein–Barr virus stable intronic sequence RNAs
References
- Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ, Hüttenhofer A (August 2009). Cullen BR (ed.). "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome". PLOS Pathogens. 5 (8): e1000547. doi:10.1371/journal.ppat.1000547. PMC 2718842. PMID 19680535.
- Gardner PP, Bateman A, Poole AM (2010). "SnoPatrol: how many snoRNA genes are there?". Journal of Biology. 9 (1): 4. doi:10.1186/jbiol211. PMC 2871523. PMID 20122292.