Embryokine

Embryokines (Greek: embryuon "embryo" + kinōs "movement") are regulatory molecules produced by the reproductive tract that modulate embryonic development.[1]

Among the molecules that function as embryokines are insulin-like growth factor-1,[2] cytokines (e.g., colony stimulating factor 2),[3] WNT regulatory proteins (i.e., DKK1[4] and members of the transforming growth factor family (e.g., activin).[5]

References
  1. Hansen PJ, Dobbs KD, Denicol AC (September 2014). "Programming of the preimplantation embryo by the embryokine colony stimulating factor 2". Animal Reproduction Science. 149 (1–2): 59–66. doi:10.1016/j.anireprosci.2014.05.017. PMID 24954585.
  2. Block J, Hansen PJ, Loureiro B, Bonilla L (December 2011). "Improving post-transfer survival of bovine embryos produced in vitro: actions of insulin-like growth factor-1, colony stimulating factor-2 and hyaluronan". Theriogenology. 76 (9): 1602–1609. doi:10.1016/j.theriogenology.2011.07.025. PMID 21890189.
  3. Hansen PJ, Dobbs KD, Denicol AC (September 2014). "Programming of the preimplantation embryo by the embryokine colony stimulating factor 2". Animal Reproduction Science. 149 (1–2): 59–66. doi:10.1016/j.anireprosci.2014.05.017. PMID 24954585.
  4. Denicol AC, Block J, Kelley KG, Dobbs KB, Mortensen CJ, Ortega MS, Hansen PJ (September 2014). "The WNT signaling antagonist Dickkopf-1 directs lineage commitment and promotes survival of the preimplantation embryo". FASEB Journal. 28 (9): 3975–3986. doi:10.1096/fj.14-253112. PMC 5395727. PMID 24858280.
  5. Yoshioka K, Suzuki C, Iwamura S (January 2000). "Effects of activin A and follistatin on developmental kinetics of bovine embryos: cinematographic analysis in a chemically defined medium". Journal of Reproduction and Fertility. 118 (1): 119–125. doi:10.1530/jrf.0.1180119. PMID 10793633.
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