Eleni Nastouli

Eleni Nastouli FRCPCH FRCPath (born Ελένη Ναστούλη, Greece) is a Consultant Clinical Virologist at University College London Hospitals NHS Foundation Trust (UCLH) and Great Ormond Street Hospital.[1][2] At UCLH Nastouli leads the Advanced Pathogen Diagnostics Unit, where she develops technologies for genome sequencing as well as studying how viruses are transmitted around hospitals. During the COVID-19 pandemic Nastouli led an investigation into infection rates amongst healthcare workers.

Eleni Nastouli

FRCPCH FRCPath
Born
Ελένη Ναστούλη

Greece
Alma materNational and Kapodistrian University of Athens
University of Manchester
Known forInfectious diseases control
Scientific career
InstitutionsUniversity College London
Imperial College London
Websitewww.uclh.nhs.uk/OurServices/Consultants/Pages/DrEleniNastouli.aspx

Early life and education

Nastouli is from Greece. She studied medicine at the National and Kapodistrian University of Athens. She moved to the United Kingdom, where she specialised in paediatrics in Manchester.

Research and career

After completing her training at the University of Manchester, Nastouli joined Imperial College London, where she trained in clinical virology.[3] She moved to University College London in 2009. At University College London Nastouli leads the Advanced Pathogen Diagnostics Unit as well as the antenatal infectious diseases clinic.[3] She looks to support pregnant women with viral infectious diseases, including Zika ad Hepatitis B.[3][4][5] She has investigated novel strategies to test for and treat HIV, Zika and Middle East respiratory syndrome (MERS).[6][7] Nastouli is the virology consultant at Great Ormond Street Hospital.[8]

In her capacity as lead of the Advanced Pathogen Diagnostics Unit, Nastouli uses information from genome sequencing to improve patient outcomes. Nastouli was made clinical lead for InfeCtion respONse through vIrus genomiCs (ICONIC), a programme that developed a mechanism to sequence the genome of viral pathogens as part of routine National Health Service services. ICONIC made us of next-generation sequencing in combination with electronic health records to allow physicians and policy makers to visualise outbreaks.[9] The electronic health records provide information about a patients journey through hospital, which makes it possible to contact-trace people who are infected with a virus.[9] It was used to control a hospital outbreak of influenza.[10] In 2018 ICONIC was awarded the Institution of Engineering and Technology (IET) Healthcare Technology award.[11][12]

Alongside her role in ICONIC, Nastouli is a member of i-sense, a consortium that looks to identify and prevent outbreaks of infectious diseases. The consortium will support communities in low and middle-income countries, where early detection and diagnosis can transform patient outcomes.[13] i-Sense makes use of a simple diagnostic tool that is connected to mobile phones, sending information wirelessly to healthcare systems.[13] By mapping indicators of emerging infections, i-sense will help global public health efforts.[13]

During the COVID-19 pandemic Nastoulli was awarded funding from the UK Research and Innovation (UKRI) to study infection rates amongst healthcare workers at UCLH.[14] Her programme, Evaluation to Inform Response Study (SAFER), will involve frequent testing as well as monitoring of healthcare worker behavior. She hopes that SAFER will help to mitigate the coronavirus outbreak, as well as inform future pandemic management strategies.[14] Nastouli is also contributing to Virus Watch, a project led by Andrew Hayward that will investigate the spread of coronavirus disease around the United Kingdom as well as analysing how social distancing impacts infection rates.[15]

Selected publications
  • Thomson, Emma C; Nastouli, Eleni; Main, Janice; Karayiannis, Peter; Eliahoo, Joseph; Muir, David; McClure, Myra O (2009). "Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV". AIDS. 23 (1): 89–93. doi:10.1097/qad.0b013e32831940a3. ISSN 0269-9370. PMC 2646374. PMID 19050390. Wikidata ()
  • Cotten, Matthew; Lam, Tommy T.; Watson, Simon J.; Palser, Anne L.; Petrova, Velislava; Grant, Paul; Pybus, Oliver G.; Rambaut, Andrew; Guan, Yi; Pillay, Deenan; Kellam, Paul (2013). "Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus". Emerging Infectious Diseases. 19 (5): 1036. doi:10.3201/eid1905.130057. ISSN 1080-6040. PMID 19733390. Wikidata ()
  • Kidd, I Michael; Down, Jim; Nastouli, Eleni; Shulman, Rob; Grant, Paul R; Howell, David CJ; Singer, Mervyn (2009). "H1N1 pneumonitis treated with intravenous zanamivir". The Lancet. 374 (9694): 1036. doi:10.1016/s0140-6736(09)61528-2. ISSN 0140-6736. PMC 3647518. PMID 23693015. Wikidata ()
  • Grant, Paul R; Turner, Melanie A; Shin, Gee Yen; Nastouli, Eleni; Levett, Lisa J (2020). "Extraction-free COVID-19 (SARS-CoV-2) diagnosis by RT-PCR to increase capacity for national testing programmes during a pandemic". bioRxiv (pre-print). doi:10.1101/2020.04.06.028316.

Awards and honours

Nastouli is a Fellow of the Royal College of Paediatrics and Child Health (FRCPCH) and a Fellow of the Royal College of Pathologists (FRCPath).

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References
  1. Eleni Nastouli publications from Europe PubMed Central
  2. Eleni Nastouli on Twitter
  3. "Dr Eleni Nastouli". uclh.nhs.uk. Retrieved 2020-04-20.
  4. Burke, Rachael M.; Pandya, Pranav; Nastouli, Eleni; Gothard, Philip (2016). "Zika virus infection during pregnancy: what, where, and why?". British Journal of General Practice. 66 (644): 122–123. doi:10.3399/bjgp16X683917. ISSN 0960-1643. PMC 4758474. PMID 26917636.
  5. Godbole, Gauri; Irish, Dianne; Basarab, Marina; Mahungu, Tabitha; Fox-Lewis, Andrew; Thorne, Claire; Jacobs, Michael; Dusheiko, Geoffrey; Rosenberg, William MC; Suri, Deepak; Millar, Andrew D. (2013). "Management of hepatitis B in pregnant women and infants: a multicentre audit from four London hospitals". BMC Pregnancy and Childbirth. 13 (1): 222. doi:10.1186/1471-2393-13-222. ISSN 1471-2393. PMC 3879069. PMID 24289183.
  6. Cotten, Matthew; Lam, Tommy T.; Watson, Simon J.; Palser, Anne L.; Petrova, Velislava; Grant, Paul; Pybus, Oliver G.; Rambaut, Andrew; Guan, Yi; Pillay, Deenan; Kellam, Paul (May 2013). "Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus". Emerging Infectious Diseases. 19 (5): 736–742. doi:10.3201/eid1905.130057. ISSN 1080-6040. PMC 3647518. PMID 23693015.
  7. "Diagnostics for the vertical transmission and paediatric studies. An article by Eleni Nastouli". zikaction.org. 2017-08-09. Retrieved 2020-04-20.
  8. "Meet the Infectious Diseases team". gosh.nhs.uk. Retrieved 2020-04-20.
  9. UCL (2018-04-26). "Real-time detection of influenza outbreaks in hospitals: demonstrating infection response through virus genomics (ICONIC)". ucl.ac.uk. UCL Institute of Health Informatics. Retrieved 2020-04-20.
  10. Houlihan, Catherine F.; Frampton, Dan; Ferns, R. Bridget; Raffle, Jade; Grant, Paul; Reidy, Myriam; Hail, Leila; Thomson, Kirsty; Mattes, Frank; Kozlakidis, Zisis; Pillay, Deenan (2018). "Use of Whole-Genome Sequencing in the Investigation of a Nosocomial Influenza Virus Outbreak". The Journal of Infectious Diseases. 218 (9): 1485–1489. doi:10.1093/infdis/jiy335. ISSN 0022-1899. PMC 6151078. PMID 29873767.
  11. UCL (2018-11-27). "UCL project tracking viruses through time and space wins at IET Awards". ucl.ac.uk. UCL Institute of Healthcare Engineering. Retrieved 2020-04-20.
  12. "UCL project tracking viruses through time and space wins at IET Awards | UCLH Biomedical Research Centre". uclhospitals.brc.nihr.ac.uk. Retrieved 2020-04-20.
  13. "About us | i-sense". i-sense.org.uk. Retrieved 2020-04-20.
  14. "COVID-19 therapy, vaccine, epidemiology and policy development research boosted by twenty-one new projects - UK Research and Innovation". ukri.org. Retrieved 2020-04-20.
  15. Greaves, Mark (17 April 2020). "'Virus Watch' study launched to monitor spread of COVID-19 across England". ucl.ac.uk. University College London.
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