EML4

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.[5]

EML4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CGC
Identifiers
Aliases	EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
External IDs	OMIM: 607442 MGI: 1926048 HomoloGene: 56841 GeneCards: EML4
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 42,169,353 bp[1] End 42,332,548 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 83,350,931 bp[2] End 83,480,361 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • molecular function Cellular component • cytoplasm • microtubule • cytoskeleton • membrane • microtubule cytoskeleton • mitotic spindle Biological process • microtubule-based process • GO:0007067 mitotic cell cycle • microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27436	78798
Ensembl	ENSG00000143924	ENSMUSG00000032624
UniProt	Q9HC35	Q3UMY5
RefSeq (mRNA)	NM_001145076 NM_019063	NM_001114361 NM_001114362 NM_001286567 NM_199466 NM_001357886 NM_001379373 NM_001379374
RefSeq (protein)	NP_001138548 NP_061936	NP_001107833 NP_001107834 NP_001273496 NP_955760 NP_001344815 NP_001366302 NP_001366303
Location (UCSC)	Chr 2: 42.17 – 42.33 Mb	Chr 17: 83.35 – 83.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143924 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032624 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
6. Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Heidebrecht HJ, Buck F, Pollmann M, et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein". Genomics. 68 (3): 348–50. doi:10.1006/geno.2000.6301. PMID 10995578.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Pollmann M, Parwaresch R, Adam-Klages S, et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation". Exp. Cell Res. 312 (17): 3241–51. doi:10.1016/j.yexcr.2006.06.035. PMID 16890222.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9HC35 (Human Echinoderm microtubule-associated protein-like 4 (EML4)) at the PDBe-KB.