Duffy binding proteins

In molecular biology, Duffy binding proteins are found in plasmodia. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa.[1][2]

Duffy binding domain
crystal structure of eba-175 region ii (rii) crystallized in the presence of (alpha)2,3-sialyllactose
Identifiers
SymbolDuffy_binding
PfamPF05424
Pfam clanCL0195
InterProIPR008602
Duffy binding protein N terminal
Identifiers
SymbolDuffyBP_N
PfamPF12377
InterProIPR021032

The presence of duffy-binding-like domains defines the family of erythrocyte binding-like proteins (EBL), a family of cell invasion proteins universal among Plasmodium. These other members may use some other receptor, for example Glycophorin A. The other universal invasion protein is reticulocyte binding protein homologs.[3] Both families are essential for cell invasion, as they function cooperatively.[4]

A duffy-binding-like domain is also found in proteins of the family Plasmodium falciparum erythrocyte membrane protein 1.

See also
  • Genetic resistance to malaria

References
  1. Adams JH, Hudson DE, Torii M, Ward GE, Wellems TE, Aikawa M, Miller LH (October 1990). "The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites". Cell. 63 (1): 141–53. doi:10.1016/0092-8674(90)90295-P. PMID 2170017.
  2. Babaeekho, L.; Zakeri, S.; Djadid, N. D. (2009). "Genetic mapping of the duffy binding protein (DBP) ligand domain of Plasmodium vivax from unstable malaria region in the Middle East". The American Journal of Tropical Medicine and Hygiene. 80 (1): 112–118. doi:10.4269/ajtmh.2009.80.112. PMID 19141848.
  3. Iyer, Jayasree; Grüner, Anne Charlotte; Rénia, Laurent; Snounou, Georges; Preiser, Peter R. (July 2007). "Invasion of host cells by malaria parasites: a tale of two protein families". Molecular Microbiology. 65 (2): 231–249. doi:10.1111/j.1365-2958.2007.05791.x. PMID 17630968.
  4. Lopaticki, Sash; Maier, Alexander G.; Thompson, Jennifer; Wilson, Danny W.; Tham, Wai-Hong; Triglia, Tony; Gout, Alex; Speed, Terence P.; Beeson, James G.; Healer, Julie; Cowman, Alan F.; Adams, J. H. (March 2011). "Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites". Infection and Immunity. 79 (3): 1107–1117. doi:10.1128/IAI.01021-10. PMC 3067488. PMID 21149582.
This article incorporates text from the public domain Pfam and InterPro: IPR008602
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