Dextran 70

Dextran 70
Clinical data
Trade names	RescueFlow, others
AHFS/Drugs.com	Monograph
Pregnancy; category	US: C (Risk not ruled out) ;
Routes of; administration	intravenous
ATC code	B05AA05 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Identifiers
CAS Number	9004-54-0;
DrugBank	DB09255;
UNII	7SA290YK68;
Chemical and physical data
Molar mass	70,000 Da

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[2]

Common side effects include vomiting, fever, and joint pains.[2] Other side effects include allergic reactions and poor blood clotting.[1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[2] It is not recommended during pregnancy.[3] It works by pulling fluid from the extravascular space into the blood vessels.[2]

Dextran 70 was approved for medical use in 1947.[4] It is on the World Health Organization's List of Essential Medicines.[5] It comes in either sodium chloride solution or glucose solution.[2]

References

World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.
"Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.
World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

External links

"Dextran 70". Drug Information Portal. U.S. National Library of Medicine.

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[WHO2008-1] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.

[AHFS2016-2] "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.

[BNF69-3] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.

[Be2012-4] BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.

[WHO21st-5] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.