Delta-like 1

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[5]

DLL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XBM
Identifiers
Aliases	DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1, NEDBAS
External IDs	OMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 170,282,206 bp[1] End 170,306,565 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 15,367,354 bp[2] End 15,376,872 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • scaffold protein binding • Tat protein binding • Notch binding • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • adherens junction • cell membrane • integral component of plasma membrane • extracellular region • cell junction • apical plasma membrane • membrane raft • cytoplasmic vesicle Biological process • Notch signaling pathway • somitogenesis • negative regulation of interleukin-10 production • proximal/distal pattern formation • cell differentiation • negative regulation of myoblast differentiation • organ growth • regulation of somitogenesis • regulation of cell division • negative regulation of neuron differentiation • loop of Henle development • negative regulation of auditory receptor cell differentiation • astrocyte development • somite specification • negative regulation of glial cell apoptotic process • negative regulation of cell differentiation • neuron fate specification • endothelial tip cell fate specification • cell-cell signaling • regulation of skeletal muscle tissue growth • marginal zone B cell differentiation • skeletal muscle tissue growth • lateral inhibition • regulation of vascular endothelial growth factor signaling pathway • neuronal stem cell population maintenance • positive regulation of sprouting angiogenesis • regulation of blood pressure • heart looping • cerebellar molecular layer formation • cell communication • positive regulation of endocytosis • retina morphogenesis in camera-type eye • proximal tubule development • negative regulation of epidermal cell differentiation • clathrin-dependent endocytosis • determination of left/right symmetry • regulation of cell adhesion • cerebellar Purkinje cell layer structural organization • compartment pattern specification • positive regulation of gene expression • retina development in camera-type eye • skin epidermis development • positive regulation of cell proliferation • nephron development • spinal cord development • cell fate determination • inner ear development • multicellular organism development • regulation of growth • Notch signaling pathway involved in arterial endothelial cell fate commitment • type B pancreatic cell development • negative regulation of epithelial cell differentiation • negative regulation of myeloid cell differentiation • positive regulation of skeletal muscle tissue growth • regulation of neurogenesis • left/right axis specification • positive regulation of Notch signaling pathway • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cardiac muscle cell differentiation • haematopoiesis • energy homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28514	13388
Ensembl	ENSG00000275555 ENSG00000198719	ENSMUSG00000014773
UniProt	O00548	Q61483
RefSeq (mRNA)	NM_005618	NM_007865 NM_001379042
RefSeq (protein)	NP_005609	NP_031891 NP_001365971
Location (UCSC)	Chr 6: 170.28 – 170.31 Mb	Chr 17: 15.37 – 15.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[5]

Interactions

Delta-like 1 has been shown to interact with NOTCH2[6][7][8]

References

1. ENSG00000198719 GRCh38: Ensembl release 89: ENSG00000275555, ENSG00000198719 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014773 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DLL1 delta-like 1 (Drosophila)".
6. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
7. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302.
8. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

Further reading

• Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
• Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718.
• Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
• Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
• Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134.
• Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135.
• Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616–25. doi:10.1182/blood.V95.5.1616.005k31_1616_1625. PMID 10688816.
• Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
• Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
• Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320.
• Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422.
• Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
• Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
• Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852.
• Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954.
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. doi:10.3892/ijo.22.5.1073. PMID 12684674.
• Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186.
• LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.