David Eisner (physiologist)

David Alfred Eisner, FRCP (Hon), FMedSci,[2] (born 3 January 1955)[1][3] is British Heart Foundation Professor of Cardiac Physiology at the University of Manchester and editor-in-chief of The Journal of General Physiology (JGP).[4]

David Eisner
David A. Eisner in 2016
Born
David Alfred Eisner

(1955-01-03) 3 January 1955
Manchester[1]
AwardsPhysiological Society Annual Review Prize Lecture (2017)
Scientific career
InstitutionsUniversity College London, University of Liverpool, University of Manchester
ThesisThe effects of sodium pump inhibition on the electrical and mechanical properties of mammalian cardiac muscle. (1979)
Doctoral advisorDenis Noble

Education

Eisner was born in 1955 in Manchester, the son of the physicist and writer Herbert Eisner.[5][3][6] After attending Manchester Grammar School, he received his B.A. in natural sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil. in physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

Career

Following postdoctoral research at the University of Cambridge on the kinetics of the sodium pump[7] in the laboratory of Ian Glynn, he took up a lectureship in the Department of Physiology at University College London in 1980. In 1990 he moved to The University of Liverpool as professor of veterinary biology. In 1999 he took up a chair of cardiac physiology at the University of Manchester and, in 2000, was awarded the BHF Chair of Cardiac Physiology.[8]

Eisner was chair of the editorial board of The Journal of Physiology from 1997 to 2000[9] and editor-in chief of the Journal of Molecular and Cellular Cardiology from 2007 to 2016. He was president of The Physiological Society from 2016 to 2018.

Research

Eisner's early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction.[10] He then investigated the control of intracellular calcium concentration[11] and its role in the production of arrhythmias.[12] He has identified the factors that regulate the calcium content of the sarcoplasmic reticulum[13][14] and how this is altered in disease.[15] His recent research has focused on the control of diastolic calcium[16][17] and the effects of calcium buffering.[18] He has also written [19] and spoken [20] about scientific reproducibility and fraud.

Personal life

Eisner is married to Susan Wray, professor of cellular and molecular physiology at the University of Liverpool, with whom he has three children.[6]

Honours and awards

Eisner was elected as a Fellow of The Academy of Medical Sciences in 1999[21] and The International Society for Heart Research in 2001.[22] and as a Member of Academia Europaea in 2007.[23] He was elected to Honorary Fellowship of The Royal College of Physicians in 2010. In 2018 he received an honorary doctorate, Doctor Honoris Causa, from The University of Debrecen.[24] Prizes awarded to him include: The GL Brown[25][26] and Annual Review Lecture[27] of The Physiological Society; the Keith Reimer Lecture[28][29] and the Peter Harris Distinguished Scientist Award of the International Society for Heart Research; the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology[30]; the Fabio Ruzzier Lecture of The Italian Physiological Society. [31] He has also delivered the Burdon-Sanderson Lecture (Oxford) in 2013.[32]

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References
  1. "CURRICULUM VITAE – David Alfred Eisner" (PDF). ae-info.org. Academia Europaea. November 2009. Retrieved 30 April 2017.
  2. "Professor of Cardiac Physiology: Prof David Eisner M.A. D.Phil, FRCP (Hon), FMedSci". University of Manchester. Retrieved 30 April 2017.
  3. ‘EISNER, Prof. David Alfred’, Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017; online edn, Oxford University Press, 2016 ; online edn, Nov 2016
  4. "Editors and Staff". rupress.org. Retrieved 2 January 2020.
  5. "Herbert Eisner". The Daily Telegraph. 28 July 2011. ISSN 0307-1235. Retrieved 17 November 2018.
  6. "European Perspectives". Circulation. 122 (3). 20 July 2010. doi:10.1161/cir.0b013e3181e8eb7f. ISSN 0009-7322.
  7. Eisner DA, Richards DE (1981). "The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts". The Journal of Physiology. 319: 403–18. doi:10.1113/jphysiol.1981.sp013917. PMC 1243847. PMID 7320919.
  8. "BHF Professor David Eisner – heart attack and arrhythmias". British Heart Foundation. Retrieved 30 April 2017.
  9. "Past Officers of the Physiological Society (1876–2001)" (PDF). physoc.org. Retrieved 30 April 2017.
  10. Eisner DA, Lederer WJ, Vaughan-Jones RD (August 1981). "The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres". The Journal of Physiology. 317: 163–87. doi:10.1113/jphysiol.1981.sp013819. PMC 1246783. PMID 7310731.
  11. Allen DG, Eisner DA, Orchard CH (May 1984). "Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle". The Journal of Physiology. 350: 615–30. doi:10.1113/jphysiol.1984.sp015221. PMC 1199289. PMID 6747860.
  12. Orchard CH, Eisner DA, Allen DG (1983). "Oscillations of intracellular Ca2+ in mammalian cardiac muscle". Nature. 304 (5928): 735–8. Bibcode:1983Natur.304..735O. doi:10.1038/304735a0. PMID 6888540.
  13. Eisner DA, Trafford AW, Díaz ME, Overend CL, O'Neill SC (June 1998). "The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation". Cardiovascular Research. 38 (3): 589–604. doi:10.1016/s0008-6363(98)00062-5. PMID 9747428.
  14. Trafford AW, Díaz ME, Eisner DA (February 2001). "Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current". Circulation Research. 88 (2): 195–201. doi:10.1161/01.res.88.2.195. PMID 11157672.
  15. Kashimura T, Briston SJ, Trafford AW, Napolitano C, Priori SG, Eisner DA, Venetucci LA (December 2010). "In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves". Circulation Research. 107 (12): 1483–9. doi:10.1161/CIRCRESAHA.110.227744. PMID 20966392.
  16. Eisner, David A.; Caldwell, Jessica L.; Trafford, Andrew W.; Hutchings, David C. (31 January 2020). "The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications". Circulation Research. 126 (3): 395–412. doi:10.1161/CIRCRESAHA.119.315891. ISSN 0009-7330. PMC 7004450. PMID 31999537.
  17. Sankaranarayanan R, Kistamás K, Greensmith DJ, Venetucci LA, Eisner DA (August 2017). "i regulates diastolic levels in rat ventricular myocytes". The Journal of Physiology. 595 (16): 5545–5555. doi:10.1113/JP274366. PMC 5556151. PMID 28617952.
  18. Smith GL, Eisner DA (May 2019). "Calcium Buffering in the Heart in Health and Disease". Circulation. 139 (20): 2358–2371. doi:10.1161/CIRCULATIONAHA.118.039329. PMC 6520234. PMID 31082292.
  19. Eisner, D. A. (January 2018). "Reproducibility of science: Fraud, impact factors and carelessness". Journal of Molecular and Cellular Cardiology. 114: 364–368. doi:10.1016/j.yjmcc.2017.10.009. ISSN 1095-8584. PMC 6565841. PMID 29079076.
  20. "Does the 'system' reward fraud?". Youtube.
  21. "Professor David Eisner | The Academy of Medical Sciences". Acmedsci.ac.uk. Retrieved 30 April 2017.
  22. "Fellows of the ISHR". International Society for Heart Research. Retrieved 30 April 2017.
  23. "Academy of Europe: Eisner David". Ae-info.org. Retrieved 30 April 2017.
  24. születnek, www.WebDeb.hu – ahol a weblapok. "University of Debrecen -". edu.unideb.hu. Retrieved 15 June 2018.
  25. "GL Brown Prize Lecture | Physiological Society". Physoc.org. 29 May 2011. Retrieved 30 April 2017.
  26. "Calcium in the heart: from physiology to disease – David Eisner (GL Brown Lecture 2014)". 16 May 2014. Retrieved 30 April 2017 – via YouTube.
  27. Eisner DA (January 2018). "Ups and downs of calcium in the heart". The Journal of Physiology. 596 (1): 19–30. doi:10.1113/JP275130. PMC 5746526. PMID 29071725.
  28. "ISHR Hall of Fame". International Society for Heart Research. Retrieved 30 April 2017.
  29. Eisner DA, Kashimura T, O'Neill SC, Venetucci LA, Trafford AW (April 2009). "What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?". Journal of Molecular and Cellular Cardiology. 46 (4): 474–81. doi:10.1016/j.yjmcc.2008.12.005. PMID 19150449.
  30. escardio (25 October 2013). "The Carmeliet-Coraboeuf-Weidmann Lecture – David Eisner". Cite journal requires |journal= (help)
  31. "Lectures". FEPS SIF 2019. Retrieved 25 June 2019.
  32. "Sir John Burdon-Sanderson Prize Lecture Series – Physiology, Anatomy and Genetics". University of Oxford. Retrieved 26 February 2020.
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