DNA damage-binding protein
DNA damage-binding protein or UV-DDB[1] is a protein complex that is responsible for repair of UV-damaged DNA.[2] This complex is composed of two protein subunits, a large subunit DDB1 (p127) and a small subunit DDB2 (p48). When cells are exposed to UV radiation, DDB1 moves from the cytosol to the nucleus and binds to DDB2, thus forming the UV-DDB complex. This complex functions in nucleotide excision repair, recognising UV-induced (6-4) pyrimidine-pyrimidone photoproducts and cyclobutane pyrimidine dimers.[1]
| damage-specific DNA binding protein 1, 127kDa | |
|---|---|
| Identifiers | |
| Symbol | DDB1 |
| Alt. symbols | XPE |
| NCBI gene | 1642 |
| HGNC | 2717 |
| OMIM | 600045 |
| RefSeq | NM_001923 |
| UniProt | Q16531 |
| Other data | |
| Locus | Chr. 11 q12-q13 |
| damage-specific DNA binding protein 2, 48kDa | |
|---|---|
| Identifiers | |
| Symbol | DDB2 |
| Alt. symbols | DBB, UV-DDB2, FLJ34321 |
| NCBI gene | 1643 |
| HGNC | 2718 |
| OMIM | 600811 |
| RefSeq | NM_000107 |
| UniProt | Q92466 |
| Other data | |
| Locus | Chr. 11 p12-p11 |
References
- Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions" (PDF). The International Journal of Biochemistry & Cell Biology. Elsevier. 43: 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.
- Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.
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