Cowdry bodies

Cowdry bodies are eosinophilic or basophilic[1] nuclear inclusions composed of nucleic acid and protein seen in cells infected with Herpes simplex virus, Varicella-zoster virus, and Cytomegalovirus. They are named after Edmund Cowdry.

There are two types of intranuclear Cowdry bodies:

  • Type A (as seen in herpes simplex and VZV) [2]
  • Type B (as seen in infection with poliovirus and CMV[3]), though it may seem that this is an antiquated and perhaps illusory type.[4]

Light microscopy is used for detection of Cowdry bodies.

References

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