Compartment (chemistry)

In chemistry, a compartment is a part of a protein that serves a specific function.[1] They are essentially protein subunits with the added condition that a compartment has distinct functionality, rather than being just a structural component.

There may be multiple compartments on one and the same protein. One example is the case of Pyruvate dehydrogenase complex. This is the enzyme which catalyses Pyruvate decarboxylation, the reaction of Pyruvate with Coenzyme A and the major entry point into the TCA cycle:

Pyruvate + Coenzyme A + NAD⁺ ⇒ acetyl-CoA + NADH + H⁺ + CO₂

Pyruvate dehydrogenase has three chemical compartments; E1 (pyruvate decarboxylase), E2 (dihydrolipoyl transacetylase) and E3 (dihydrolipoyl dehydrogenase). Each one of the compartments has its own specific function.

References

Giessen, Tobias W.; Silver, Pamela A. (2016). "Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles". ACS Synthetic Biology. 5 (12): 1497–1504. doi:10.1021/acssynbio.6b00117. PMID 27276075.

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[1] Giessen, Tobias W.; Silver, Pamela A. (2016). "Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles". ACS Synthetic Biology. 5 (12): 1497–1504. doi:10.1021/acssynbio.6b00117. PMID 27276075.