Cold capsule

Cold Capsule IV and Cold Capsule V were extended release oral capsules (pill) used to control cold symptoms.

Composition

Both products contained chlorpheniramine maleate (an antihistamine) and phenylpropanolamine hydrochloride (a decongestant) but differed in their doses. Both products contained 75 mg of phenylpropanolamine hydrochloride, but Cold Capsule IV contained 12 mg chlorpheniramine maleate while Cold Capsule V had 8 mg[1] .

History

They was manufactured by Graham DM and both approved for use by the U.S. Food and Drug Administration in 1985.

In 2000 the FDA issued an advisory for all products containing phenylpropanolamine due to the risk of stroke[2] and recommended their recall. Both Cold Capsule products are now Discontinued.

gollark: No, I mean it could give one or the other a non-population-related advantage due to differences in the geometry of some kind.
gollark: I guess it's possible that even one which doesn't know about parties might accidentally be biased due to (hypothetically, I don't know if this is true) one party being popular in low-density areas and the other in high-density, or really any other difference in locations.
gollark: You don't actually need simple shapes very badly as long as you have an algorithm which is not likely to be biased.
gollark: Okay, rearrange the states so they're square.
gollark: A simple if slightly inaccurate way would be some kind of binary space partitioning thing, where (pretending the US is a perfect square) you just repeatedly divide it in half (alternatingly vertically/horizontally), but stop dividing a particular subregion when population goes below some target number.

References
  1. http://drugpatentwatch.com/p/tradename/COLD+CAPSULE+IV, "Profile for Tradename: COLD CAPSULE IV", DrugPatentWatch.com
  2. https://www.fda.gov/cder/drug/infopage/ppa/advisory.htm Food and Drug Administration Public Health Advisory, "Safety of Phenylpropanolamine", www.FDA.gov


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