Clear cell acanthoma

Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos acanthoma," and "Pale cell acanthoma") is a benign clinical and histological lesion initially described as neoplastic, which some authors now regard as a reactive dermatosis. It usually presents as a moist solitary firm, brown-red, well-circumscribed, 5 mm to 2 cm nodule or plaque on the lower extremities of middle-aged to elderly individuals The lesion has a crusted, scaly peripheral collarette and vascular puncta on the surface. It is characterized by slow growth, and may persist for years. The clinical differential diagnosis includes: dermatofibroma, inflamed seborrheic keratosis, pyogenic granuloma, basal cell carcinoma, squamous cell carcinoma, verruca vulgaris, psoriatic plaque, and melanoma.

Clear cell acanthoma
Clear cell acanthoma (Degos)
SpecialtyOncology 

Histology

Clear cell acanthoma is characterized by a sharply demarcated psoriasiform epidermal hyperplasia composed of a proliferation of slightly enlarged keratinocytes, and basal cells with pale-staining glycogen-rich cytoplasm, mild spongiosis and scattered neutrophils, which may form small intraepidermal microabscesses. Oedematous dermal papillae are typically seen with increased vascularity and a mixed inflammatory infiltrate including lymphocytes, plasma cells and neutrophils.

Treatment

Simple surgical excision is curative. [1]:636[2]:777

gollark: But there would also be a popup asking you to download the app, which would not actually work because I'm not making an app, as well as one asking you to add it to your home screen as a PWA.
gollark: Then it would load into a page containing a bunch of links to all the actual *content*, but each would have a vaguely nice-looking but irrelevant image to occupy half the page and also your internet connection.
gollark: The loading spinner would load after it's about half done with the whole thing.
gollark: "osmarks.tk 2.0" would start by having a splash screen with an overlarge image and text saying things like "downloading 5MB of JS frameworks", "finding irrelevant images for all content", "running `npm update`", that sort of thing.
gollark: Do you mean "enraged", sinth?

See also

References
  1. Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.CS1 maint: multiple names: authors list (link)
  2. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.