Chromatid

A chromatid (Greek khrōmat- 'color' + -id) is a chromosome that has been newly copied or the copy of such a chromosome, the two of them still joined to the original chromosome by a single centromere.

In the diagram, (1) refers to a chromatid: 1-half of two identical threadlike strands of a replicated chromosome. During cell division, the identical copies (called a "sister chromatid pair") are joined at the region called the centromere (2). Once the paired sister chromatids have separated from one another (in the anaphase of mitosis) each is known as a daughter chromosome. The short arm of the right chromatid (3), and the long arm of the right chromatid (4), are also marked.

Before replication, one chromosome is composed of one DNA molecule. Following replication, each chromosome is composed of two DNA molecules; in other words, DNA replication itself increases the amount of DNA but does not (yet) increase the number of chromosomes. The two identical copies—each forming one half of the replicated chromosome—are called chromatids.[1] During the later stages of cell division these chromatids separate longitudinally to become individual chromosomes.[2]

Chromatid pairs are normally genetically identical, and said to be homozygous; however, if mutation(s) occur, they will present slight differences, in which case they are heterozygous. The pairing of chromatids should not be confused with the ploidy of an organism, which is the number of homologous versions of a chromosome.

Chromonema is the fibre-like structure in prophase in the primary stage of DNA condensation. In metaphase, they are called chromatids.

Sister chromatids
Main article: Sister chromatids
Condensation and resolution of human sister chromatids in early mitosis

Chromatids may be sister or non-sister chromatids. A sister chromatid is either one of the two chromatids of the same chromosome joined together by a common centromere. A pair of sister chromatids is called a dyad. Once sister chromatids have separated (during the anaphase of mitosis or the anaphase II of meiosis during sexual reproduction), they are again called chromosomes, each having the same genetic mass as one of the individual chromatids that made up its parent. The DNA sequence of two sister chromatids is completely identical (apart from very rare DNA copying errors).

Sister chromatid exchange (SCE) is the exchange of genetic information between two sister chromatids. SCEs can occur during mitosis or meiosis. SCEs appear to primarily reflect DNA recombinational repair processes responding to DNA damage (see articles Sister chromatids and Sister chromatid exchange).

Non-sister chromatids, on the other hand, refers to either of the two chromatids of paired homologous chromosomes, that is, the pairing of a paternal chromosome and a maternal chromosome. In chromosomal crossovers, non-sister (homologous) chromatids form chiasmata to exchange genetic material during the prophase I of meiosis (See Homologous chromosome pair).

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References
  1. "What is a Chromatid?". About.com. Retrieved 18 July 2017.
  2. "Definition of CHROMATID". www.Merriam-Webster.com. Retrieved 18 July 2017.
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