Cartilage-derived angiogenesis inhibitor

A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I[1] and chondromodulin I.[2]

The antiangiogenic effect may be an inhibition of basement membrane degradation.

References
  1. Kern BE, Balcom JH, Antoniu BA, Warshaw AL, Fernández-del Castillo C (2003). "Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer". J. Gastrointest. Surg. 7 (8): 961–8, discussion 969. doi:10.1016/j.gassur.2003.08.003. PMID 14675705.
  2. Setoguchi K, Misaki Y, Kawahata K, et al. (March 2004). "Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis". Arthritis Rheum. 50 (3): 828–39. doi:10.1002/art.20193. PMID 15022325.


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