Carbonic anhydrase III, muscle specific

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.[5]

CA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA3, CAIII, Car3, carbonic anhydrase 3
External IDsOMIM: 114750 MGI: 88270 HomoloGene: 31298 GeneCards: CA3
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.2Start85,373,436 bp[1]
End85,449,040 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

761

12350

Ensembl

ENSG00000164879

ENSMUSG00000027559

UniProt

P07451

P16015

RefSeq (mRNA)

NM_005181

NM_007606

RefSeq (protein)

NP_005172

NP_031632

Location (UCSC)Chr 8: 85.37 – 85.45 MbChr 3: 14.86 – 14.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients.[6] A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.[7] The gene spans 10.3 kb and contains seven exons and six introns.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000164879 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027559 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shima K, Tashiro K, Hibi N, Tsukada Y, Hirai H (Jun 1983). "Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle". Acta Neuropathol. 59 (3): 237–9. doi:10.1007/BF00703210. PMID 6221502.
  6. Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients". Autoimmunity. 42 (3): 209–15. doi:10.1080/08916930802668610. PMID 19301202.
  7. Liu C, Wei Y, Wang J, Pi L, Huang J, Wang P (Sep 2012). "Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure". Clin Dev Immunol. 2012: 354594. doi:10.1155/2012/354594. PMC 3461255. PMID 23049597.
  8. "Entrez Gene: CA3 carbonic anhydrase III, muscle specific".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P07451 (Carbonic anhydrase 3) at the PDBe-KB.


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