Capillaria aerophila

Capillaria aerophila
	Capillaria aerophila ; in the trachea of a fox [1]
Scientific classification
Kingdom:	Animalia
Phylum:	Nematoda
Class:	Enoplea
Order:	Enoplida
Family:	Capillariidae
Genus:	Capillaria
Species:	C. aerophila
Binomial name
	Capillaria aerophila; (Creplin, 1839)

Capillaria aerophila is a nematode parasite found in the respiratory tract of foxes,[1] dogs,[2] and various other carnivorous mammals.[3] A few cases of human infestation have also been reported. Though it is sometimes called a "lungworm", this term usually refers to other species of nematodes. Infestation by C. aerophila is referred to as "pulmonary capillariasis" (occasionally spelled "capillariosis), "bronchial capillariasis," or (rarely) "thominxosis." This parasite has a direct life cycle, meaning that the life cycle can be completed in a single host. C. aerophila usually causes only minor clinical symptoms, such as irritation of the respiratory tract and coughing. However, secondary bacterial infections of the respiratory tract, including pneumonia, may develop in heavy infestations. Treatment with anthelmintics, such as levamisole or fenbendazole, is usually sufficient to cure C. aerophila infestations.

Taxonomy and description

This species was originally described in 1839, from specimens found in the trachea of a wolf, and named Trichosoma aerophila.[4] It was transferred to the genus Eucoleus (as Eucoleus aerophilus) by Dujardin in 1845, and to the genus Capillaria (as Capillaria aerophila) in 1911, and is sometimes referred to as Thominx aerophilum. The changes to the end of the species name in each genus, whether it ends with "-a", "-us" or "-um", are necessary to adhere to the rules of Latin grammar.

Males generally range from 15–25 mm long, with a maximum width of 62 µm, while females are 18–32 mm long with a maximum width of 105 µm. Some sources report that they are larger when they occur in the nasal sinuses.[5]

Hosts and distribution

Capillaria aerophila has been found on every continent, and occurs in dogs, cats, and a wide range of wild mammals. The following species have been reported as hosts:

American marten (Martes americana) in North America
American black bear (Ursus americanus) in North America
Arctic fox (Alopex lagopus) in Iceland
Badger (Taxidea taxus) in North America
Beech marten (or stone marten; Martes foina) in Europe
Bobcat (Lynx rufus) in North America
Brown bear (Ursus arctos caucasicus) in Russia
Cat (Felis catus) in Asia, Australia, Europe, New Zealand, North America, and South America
Coyote (Canis latrans) in North America
Crab-eating fox (Cerdocyon thous) in South America
Dog (Canis lupus familiaris) in Asia, Europe, North America, South America
Egyptian mongoose (Herpestes ichneumon) in Europe (Republic of Buryatia)
Eurasian lynx (Lynx lynx) in Europe
European pine marten (Martes martes) in Europe
European polecat (Mustela putorius) in Europe
Florida panther (Puma concolor coryi) in North America
Golden jackal (Canis aureus) in Azerbaijan
Gray fox (Urocyon cinereoargenteus) in North America
Gray wolf (Canis lupus) in Europe
Hedgehog (Erinaceus sp.) in Europe, New Zealand
Human (Homo sapiens) only a few cases reported in Europe, Iran and Morocco
Iberian lynx (Lynx pardinus) in Europe
Iriomote cat (Prionailurus iriomotensis) in Japan
Japanese marten (Martes melampus) in Japan
Kit fox (Vulpes macrotis) in North America
Leopard cat (Prionailurus bengalensis euptailurus) in Japan
Opossum (Didelphis virginiana) in North America
Raccoon (Procyon lotor) in North America
Raccoon dog (Nyctereutes procyonoides) in Europe and Japan
Red fox (Vulpes vulpes) in Europe and North America
Sable (Martes zibellina) in Buryatia (Asia)
Wildcat (Felis silvestris) in Europe

Life cycle

Capillaria aerophila has a direct life cycle, meaning that it can be completed in one host. The adults lay eggs in the lungs. The eggs are coughed up and swallowed by the host; and are then passed in the feces. In about 5–7 weeks, the larvae develop into the infective stage within the egg envelope in the soil. The infective larvae remain viable for up to 1 year. When a suitable host eats these mature eggs, the larvae hatch in the intestines and migrate to the lungs. They mature into adults about 40 days post-infection. Earthworms may act as intermediate hosts, by eating the C. aerophila eggs and infecting mammalian hosts when eaten by the mammals. However, the involvement of the earthworms is not necessary for the completion of the C. aerophila life cycle.

Prevalence

Reported infestation rates in dogs and cats which are kept as pets in Europe and North America are generally less than 10%. In wildlife, rates as high as 74%[6] and 88%[7] have been reported for wild foxes.

Clinical symptoms

Most cases of Capillaria aerophila infestation in dogs and cats are without serious clinical symptoms. Heavy infestations may result in inflammation of the respiratory tract (rhinitis, tracheitis or bronchitis), or secondary bacterial infections of the respiratory tract, including bronchopneumonia. These developments are usually characterized by a whistling sound when the animal breathes, frequent sneezing, or a deep, wheezing cough.

In humans, symptoms include coughing, fever, bronchitis, dyspnea (shortness of breath), blood in the saliva, and elevated levels of eosinophils in the blood (eosinophilia).

Most reports of C. aerophila in wildlife are simply parasite field surveys, and do not mention specific symptoms. However, the involvement of C. aerophila infestation and pneumonia, in addition to other parasites, in the death of an opossum has been reported.[8]

Diagnosis, treatment and prevention

Infestation is easily diagnosed by the presence of C. aerophila eggs in the nasal or tracheal lavage, or the feces of infested animals. Standard anthelmintics, such as ivermectin or fenbendazole, are recommended for treatment of dogs.[3] Humans infested with C. aerophila have been successfully treated with albendazole and mebendazole.[9]

For animals kept in outdoor pens, proper drainage and allowing sunlight to hit the floor of the pen have been suggested to minimize the spread of infestation.[10]

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References

Lalošević, V.; Lalošević, D.; Čapo, I.; Simin, V.; Galfi, A. & Traversa, D. (2013). "High infection rate of zoonotic Eucoleus aerophilus infection in foxes from Serbia". Parasite. 20 (3): 3. doi:10.1051/parasite/2012003. PMC 3718516. PMID 23340229.
Magi, M.; Guardone, L.; Prati, M. C.; Torracca, B.; Macchioni, F. (2012). "First report of Eucoleus boehmi (syn. Capillaria boehmi) in dogs in north-western Italy, with scanning electron microscopy of the eggs". Parasite. 19 (4): 433–435. doi:10.1051/parasite/2012194433. PMC 3671462. PMID 23193529.
"Capillaria aerophila, The Merck Veterinary Manual". Merck & Co. Retrieved 2008-11-26.
Cross, J.H. (1998) "Capillaria aerophila." In: S.R. Palmer, Lord Soulsby and D.I.H. Simpson (eds) "Zoonoses: Biology, Clinical Practice and Public Health Control." Oxford University Press: Oxford, England. ISBN 0-19-262380-X. pp. 767-769.
Banzon, T. (1982) "Capillariasis". In: M.G. Schultz (ed) Handbook Series in Parasitic Zoonoses, Section C. Parasitic Zoonoses, Volume II. CRC Press: Boca Raton, FL. ISBN 0-8493-2917-5, pp. 63-65.
Saeed I, Maddox-Hyttel C, Monrad J, Kapel CM (June 2006). "Helminths of red foxes (Vulpes vulpes) in Denmark". Vet. Parasitol. 139 (1–3): 168–79. doi:10.1016/j.vetpar.2006.02.015. PMID 16580775.
Davidson RK, Gjerde B, Vikøren T, Lillehaug A, Handeland K (March 2006). "Prevalence of Trichinella larvae and extra-intestinal nematodes in Norwegian red foxes (Vulpes vulpes)". Vet. Parasitol. 136 (3–4): 307–16. doi:10.1016/j.vetpar.2005.11.015. PMID 16378689.
Nettles V.F.; Prestwood A.; Davidson W.R. (1975). "Severe parasitism in an opossum" (PDF). Journal of Wildlife Diseases. 11 (3): 419–420. doi:10.7589/0090-3558-11.3.419. PMID 1152183.
Lalosević D, Lalosević V, Klem I, Stanojev-Jovanović D, Pozio E (January 2008). "Pulmonary capillariasis miming bronchial carcinoma". Am. J. Trop. Med. Hyg. 78 (1): 14–6. doi:10.4269/ajtmh.2008.78.14. PMID 18187778.
Soulsby, E.J. (1982) Helminths, Arthropods and Protozoa of Domesticated Animals. 7th Edition. Lea & Febiger: Philadelphia. ISBN 0-7020-0820-6. pp. 340-341.